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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제22권 제1호
- 발행연도
- 2017.1
- 수록면
- 15 - 26 (12page)
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The prevalence of type 2 diabetes (T2D) is increasing worldwide. Patients with T2D suffer from various diabetes-related complications. Since there are many patients with T2D that cannot be controlled by previously developed drugs, it has been necessary to develop new drugs, one of which is a glucagon-like peptide-1 (GLP-1) based therapy. GLP-1 has been shown to ameliorate diabetes-related conditions by augmenting pancreatic β-cell insulin secretion and having the low risk of causing hypoglycemia. Because of a very short half-life of GLP-1, many researches have been focused on the development of GLP-1 receptor (GLP-1R) agonists with long half-lives such as exenatide and dulaglutide. Now GLP-1R agonists have a variety of dosing-cycle forms to meet the needs of various patients. In this article, we review the physiological features of GLP-1, the effects of GLP-1 on T2D, the features of several GLP-1R agonists, and the therapeutic effect on T2D.
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참고문헌 (22)
참고문헌 신청
Baggio LL / 2007 / Biology of incretins: GLP-1 and GIP / Gastroenterology 132 : 2131 ~ 2157
Buse JB / 2009 / Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallelgroup, multinational, open-label trial (LEAD-6) / Lanc
Drucker DJ / 2008 / Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, openlabel, non-inferiority study / Lancet 372 : 1240 ~ 1250
Garber AJ / 2013 / AACE comprehensive diabetes management algorithm 2013 / Endocr Pract 19 : 327 ~ 336
Gupta V / 2013 / Glucagon-like peptide-1 analogues: an overview / Indian J Endocrinol Metab 17 : 413 ~ 421
Buse JB / 2009 / Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallelgroup, multinational, open-label trial (LEAD-6) / Lanc
Drucker DJ / 2008 / Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, openlabel, non-inferiority study / Lancet 372 : 1240 ~ 1250
Garber AJ / 2013 / AACE comprehensive diabetes management algorithm 2013 / Endocr Pract 19 : 327 ~ 336
Gupta V / 2013 / Glucagon-like peptide-1 analogues: an overview / Indian J Endocrinol Metab 17 : 413 ~ 421
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