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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.3
- 수록면
- 20 - 25 (6page)
- DOI
- http://dx.doi.org/10.13041/jpvm.2017.41.1.20
이용수
초록· 키워드
오류제보하기
Many kinds of medicinal herbs have been used to treat inflammation in Oriental medicine. However, there few studies have investigated the anti-inflammatory activity of medicinal herbs. In this study, we used mouse bone marrow cells (BMs) treated with lipopolysaccharide (LPS), a simulator of osteomyelitis, to screen medicinal herbs having anti-inflammatory activity.
Specifically, we investigated the activity of an extract of Rhus chinensis (RC) using metabolic activity and cytokine production of the BMs treated with LPS and RC. The metabolic activity of BMs was measured using Cell Counting Kit-8® solution. RC decreased the metabolic activity of LPS-treated BMs. A viability assay using trypan blue solution demonstrated that RC marginally decreased the viability of LPS-treated BMs. Flow cytometry analysis revealed that RC decreased the mitochondrial membrane potential of BMs, regardless of LPS treatment. To investigate the anti-inflammatory activity of RC, we measured the production of tumor necrosis factor (TNF)-alpha and interleukin (IL)-10 in BMs. LPS increased the production of both cytokines in BMs. Interestingly, RC induced a greater increase in IL-10 than TNF-alpha in LPS-treated BMs. Taken together, RC decreased metabolic activity and modulated the production of inflammation-related cytokines in LPS-treated BMs. These findings suggest that RC can be used as a medicinal herb with anti-inflammatory activity.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Buer JK / 2014 / Origins and impact of the term ‘NSAID’ / Inflammopharmacology 22:263~267
Chen LB / 1988 / Mitochondrial membrane potential in living cells / Annu Rev Cell Biol 4:155~181
Djakpo O / 2010 / Rhus chinensis and Galla chinensisfolklore to modern evidence: review / Phytother Res 24:1739~1747
하희정 / 2011 / 국내에서 연구된 항염 효능이 있는 한약재의 본초학적 분석 / 대한본초학회지 26(4):15~22
Yong Han / 2015 / Protective effects of fucoidan on the cell death of spleen cells induced by taxol / 예방수의학회지 39(4):185~188
Chen LB / 1988 / Mitochondrial membrane potential in living cells / Annu Rev Cell Biol 4:155~181
Djakpo O / 2010 / Rhus chinensis and Galla chinensisfolklore to modern evidence: review / Phytother Res 24:1739~1747
하희정 / 2011 / 국내에서 연구된 항염 효능이 있는 한약재의 본초학적 분석 / 대한본초학회지 26(4):15~22
Yong Han / 2015 / Protective effects of fucoidan on the cell death of spleen cells induced by taxol / 예방수의학회지 39(4):185~188
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