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논문 기본 정보

자료유형
학술저널
저자정보
Seon Woo Yoo (Jeonbuk National University Medical School and Hospital) Ki Minjong (Jeonbuk National University Medical School and Hospital) Kim Dal (Jeonbuk National University Hospital) Kim Seul Ki (Jeonbuk National University Hospital Jeonju) 박승용 (전북대학교 의과대학 내과학교실) 한효진 (전북대학교) 이흥범 (전북대학교)
저널정보
대한중환자의학회 Acute and Critical Care Acute and Critical Care 제36권 제4호
발행연도
2021.11
수록면
322 - 331 (10page)
DOI
10.4266/acc.2021.00276

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Background The molecular adsorbent recirculating system (MARS) is a hepatic replacement system that supports excretory liver function in patients with liver failure. However, since MARS has been employed in our hospital, bleeding complications have occurred in many patients during or after MARS. The objective of this study was to determine how MARS affects coagulopathy and identify specific factors associated with bleeding complications. Methods We retrospectively analyzed data from 17 patients undergoing a total of 41 MARS sessions. Complete blood count, coagulation profiles, and blood chemistry values were compared before and after MARS. To identify pre-MARS factors associated with increased bleeding after MARS, we divided patients into bleeder and non-bleeder groups and compared their pre-MARS laboratory values. Results MARS significantly reduced bilirubin and creatinine levels. MARS also increased prothrombin time and reduced platelet and fibrinogen, thus negatively impacting coagulation. Pre-MARS hemoglobin was significantly lower in the bleeder group than in the non-bleeder group (P=0.015). When comparing the upper and lower 33% of MARS sessions based on the hemoglobin reduction rate, hemoglobin reduction was significantly greater in MARS sessions involving patients with low pre-MARS international normalized ratio of prothrombin time (PT-INR) and factor V (P=0.038 and P=0.023, respectively). Conclusions MARS could appears to alter coagulation-related factors such as factor V and increase the risk of bleeding complications particularly in patient with low hemoglobin. However, individual differences among patients were large, and various factors, such as low hemoglobin, PT-INR, and factor V levels, appear to be involved.

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