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Laser-assisted Delivery of a Combined Antioxidant Formulation Enhances the Clinical Efficacy of Fractional Microneedle Radiofrequency Treatment: A Pilot Study
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논문 기본 정보

Type
Academic journal
Author
Jihee Kim (Department of Dermatology and Cutaneous Biology Research Institute Severance Hospital Yonsei Univer) Soo Min Kim (Department of Dermatology and Cutaneous Biology Research Institute Severance Hospital Yonsei Univer) Bok Ki Jung (Department of Plastic and Reconstructive Surgery Yongin Severance Hospital Yongin Korea)
Journal
대한의학레이저학회 MEDICAL LASERS Medical Lasers 제10권 제3호 KCI Accredited Journals
Published
2021.9
Pages
161 - 169 (9page)
DOI
10.25289/ML.2021.10.3.161

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Laser-assisted Delivery of a Combined Antioxidant Formulation Enhances the Clinical Efficacy of Fractional Microneedle Radiofrequency Treatment: A Pilot Study
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Background and Objectives Fractional microneedle radiofrequency systems are popular options to increase elasticity in aging skin. Laser-assisted drug delivery is a promising method for the epidermal injection of topically applied drugs and cosmetic ingredients. This study assesses the safety and efficacy of topical delivery of L-ascorbic acid, vitamin E, and ferulic acid after fractional microneedle radiofrequency treatment for reducing photodamage. Materials and Methods In this prospective, single-center, split-face, controlled pilot study, six women (mean age, 48.0 years; range, 35-57 years; Fitzpatrick skin types III and IV) exhibiting mild to moderate photodamage, underwent a single session of fractional microneedle radiofrequency treatment. The patients were instructed to apply the antioxidant formulation to only one side of the face. Patients were evaluated 3 days, 7 days, and 4 weeks thereafter, using three-dimensional imaging and ultrasound. Ex vivo , the fullthickness human skin was used for molecular and histological evaluation. Statistical analysis was achieved by applying t-tests, Mann- Whitney U tests, and one-way analyses of variance. Results Compared to the untreated side, the antioxidant-treated side exhibited a significant increase in dermal thickness (10.32% vs. 17.54%, p < 0.05), but not in skin elasticity (4.76% vs. 4.69%, p > 0.05). The difference in erythema between the sides was statistically not significant (p > 0.05). In the ex vivo model, expression of FGF2 in the skin was significantly increased after application of the antioxidant formulation, as compared to results obtained subsequent to fractional microneedle radiofrequency treatment only (p < 0.01). Conclusion This study demonstrates that for the treatment of photodamaged skin, laser-assisted delivery of the antioxidant formulation is a safe and effective adjuvant modality following fractional microneedle radiofrequency.
#Energy-based device #Fractional microneedle radiofrequency #Laserassisted drug delivery #Skin aging #Antioxidant

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References (27)

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Nkengne A / 2013 / Aging and facial changes--documenting clinical signs, part 1 : clinical changes of the aging face / Skinmed 11:281~286 google schola Britt CJ / 2017 / Energy-based facial rejuvenation : advances in diagnosis and treatment / JAMA Facial Plast Surg 19:64~71 google schola Gold MH / 2017 / The future of non-invasive rejuvenation technology : devices / J Drugs Dermatol 16:s104~s107 google schola Hantash BM / 2009 / Bipolar fractional radiofrequency treatment induces neoelastogenesis and neocollagenesis / Lasers Surg Med 41:1~9 google schola Manuskiatti W / 2016 / Thermal response of in vivo human skin to fractional radiofrequency microneedle device / Biomed Res Int 2016:6939018 google schola

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