지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 522 - 530 (9page)
- DOI
- 10.5021/ad.2021.33.6.522
이용수
초록· 키워드
오류제보하기
Background: Melasma shows characteristic histological features of photoaged skin. Objective: We evaluated the effect of dermal rejuvenation using a temperature-controlled continuous non-invasive radiofrequency (RF) device on melasma.
Methods: Continuous skin heating at the temperature of 43°C for 20 minutes was performed in ten subjects with melasma who underwent 3 tri-weekly RF sessions. Pigmentation was evaluated with Mexameter® and investigator’s global assessment (IGA). Immunohistochemi- cal staining and image analysis was performed to evaluate biopsies from melasma skin before and after the treatment.
Results: The lesional melanin index was decreased by 13.7% at week 9. IGA score was im- proved from 3.50 at baseline to 2.95 at week 9. No significant adverse event was reported. Histologic analysis revealed reduced melanin and increased collagen density and thickness. The expression of procollagen-1 and type IV collagen was increased after the treatment. The number of p16INK4A-positive senescent fibroblasts was reduced after the treatment, while the expression of heat shock protein 70 and 90 was increased. Stromal derived factor-1, a senes- cence-associated anti-melanogenic factor secreted from the fibroblasts, was up-regulated after the treatment, while the level of c-kit was not changed.
Conclusion: Thermal skin stimulation by the temperature-controlled continuous RF device improved melasma through dermal rejuvenation.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Newcomer VD / 1961 / A melanosis of the face("chloasma") / Arch Dermatol 83:284~299
Lee AY / 2015 / Recent progress in melasma pathogenesis / Pigment Cell Melanoma Res 28:648~660
Passeron T / 2018 / Melasma, a photoaging disorder / Pigment Cell Melanoma Res 31:461~465
Kwon SH / 2019 / Melasma : updates and perspectives / Exp Dermatol 28:704~708
Kwon SH / 2016 / Heterogeneous pathology of melasma and its clinical implications / Int J Mol Sci 17:824
Lee AY / 2015 / Recent progress in melasma pathogenesis / Pigment Cell Melanoma Res 28:648~660
Passeron T / 2018 / Melasma, a photoaging disorder / Pigment Cell Melanoma Res 31:461~465
Kwon SH / 2019 / Melasma : updates and perspectives / Exp Dermatol 28:704~708
Kwon SH / 2016 / Heterogeneous pathology of melasma and its clinical implications / Int J Mol Sci 17:824
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