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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 283 - 290 (8page)
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초록· 키워드
오류제보하기
Background: Fractional laser resurfacing treatment has been extensively investigated and is widely used. However, the mechanism underlying its effects is poorly understood because of the ethical and cosmetic problems of obtaining skin biopsies required to study the changes after laser treatment.
Objective: To evaluate the usefulness of human skin explants for the investigation of fractional photothermolysis.
Methods: Full-thickness discarded skin was treated in 4 ways: no treatment (control), fractional carbon dioxide laser, fractional Er:YAG laser, and fractional 1,550-nm erbium- doped fiber laser. Both treated and non-treated skin samples were cultured ex vivo at the air-medium interface for 7 days. Frozen tissue was sectioned and stained with hematoxylin & eosin for histologic examination and nitro blue tetrazolium chloride for viability testing. Results: Skin explants cultured for up to 3 days exhibited histologic changes similar to those observed in in vivo studies, including microscopic treatment zones surrounded by a thermal coagulation zone, re-epithelialization, and formation of microscopic epidermal necrotic debris. However, the explant structure lost its original form within 7 days of culture. The viability of skin explants was maintained for 3 days of culture but was also lost within 7 days. Conclusion: The skin explant model may be a useful tool for investigating the immediate or early changes following fractional photothermolysis, but further improvements are required to evaluate the long-term and dermal changes.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Alster TS / 1996 / Resurfacing of atrophic facial acne scars with a high-energy, pulsed carbon dioxide laser / Dermatol Surg 22 : 151 ~ 154
Bedi VP / 2007 / The effects of pulse energy variations on the dimensions of microscopic thermal treatment zones in nonablative fractional resurfacing / Lasers Surg Med 39 :
Bernstein LJ / 1998 / Scar resurfacing with high-energy, short-pulsed and flashscanning carbon dioxide lasers / Dermatol Surg 24 : 101 ~ 1
Collins KB / 2000 / Development of an in vitro organ culture model to study transmission of HIV-1 in the female genital tract / Nat Med 6 : 475 ~ 479
Companjen AR / 2001 / A modified ex vivo skin organ culture system for functional studies / Arch Dermatol Res 293 : 184 ~ 190
Bedi VP / 2007 / The effects of pulse energy variations on the dimensions of microscopic thermal treatment zones in nonablative fractional resurfacing / Lasers Surg Med 39 :
Bernstein LJ / 1998 / Scar resurfacing with high-energy, short-pulsed and flashscanning carbon dioxide lasers / Dermatol Surg 24 : 101 ~ 1
Collins KB / 2000 / Development of an in vitro organ culture model to study transmission of HIV-1 in the female genital tract / Nat Med 6 : 475 ~ 479
Companjen AR / 2001 / A modified ex vivo skin organ culture system for functional studies / Arch Dermatol Res 293 : 184 ~ 190
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