지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
A 30-year-old male with an 8-year history of plaque-type psoriasis visited our dermatologic clinic. His past medical and family history were non-contributory to the chief complaint. Since 30 weeks of oral systemic therapy provided an inadequate response to symptoms, secukinumab administration was started. Four weeks after secukinumab injection, the patient complained of abdominal pain and diarrhea, followed gradually by bloody stool and severe abdominal pain. A colonoscopic biopsy was performed, which showed chronic active inflammation with cryptitis and crypt abscess. Ulcerative colitis (UC) was suspected to be associated with secukinumab; hence, we changed the drug to guselkumab. Twelve weeks after treatment with guselkumab, UC-associated symptoms markedly improved. In this report, we present a case of UC following secukinumab treatment for psoriasis. There have been several reports of the association between Interleukin-17 inhibitors and inflammatory bowel disease (IBD); however, clear mechanisms and causality remain unestablished. Thus, based on available evidence, the possibility of new-onset or exacerbation of underlying IBD should not be overlooked when selecting a biologic treatment for psoriatic patients.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Darch KM / 2020 / Secukinumab-Induced Inflammatory Bowel Disease in a Patient Treated for Chronic Plaque Psoriasis and Psoriatic Arthritis: A Case Report and Review of the Role of Novel Biologic Agents Targeting the p19 Subunit of IL-23 / Case Rep Med 2020:9404505
Chiricozzi A / 2013 / IL-17 targeted therapies for psoriasis / Expert Opin Investig Drugs 22(8):993~1005
Onac IA / 2021 / Secukinumab as a potential trigger of inflammatory bowel disease in ankylosing spondylitis or psoriatic arthritis patients / Rheumatology
Silva FA / 2016 / The Immunological Basis of Inflammatory Bowel Disease / Gastroenterol Res Pract 2016:2097274
Fauny M / 2020 / Paradoxical gastrointestinal effects of interleukin-17 blockers / Ann Rheum Dis 79(9):1132~1138
Chiricozzi A / 2013 / IL-17 targeted therapies for psoriasis / Expert Opin Investig Drugs 22(8):993~1005
Onac IA / 2021 / Secukinumab as a potential trigger of inflammatory bowel disease in ankylosing spondylitis or psoriatic arthritis patients / Rheumatology
Silva FA / 2016 / The Immunological Basis of Inflammatory Bowel Disease / Gastroenterol Res Pract 2016:2097274
Fauny M / 2020 / Paradoxical gastrointestinal effects of interleukin-17 blockers / Ann Rheum Dis 79(9):1132~1138
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