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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 194 - 204 (11page)
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The anti-obesity effect of a mixture of Bifidobacterium animalis subsp. lactis CP-9 and Lactobacillus rhamnosus bv-77 in an obese mouse model was studied. Obesity was induced in C57BL/6J mice by providing a 60 kcal% high fat diet (HFD) for 7 weeks. The mice were then administered probiotics for 5 weeks and divided into five groups as follows: (1) normal control group (10 kcal% fat diet), (2) HFD group (60 kcal% fat diet), (3) low dose-treated group (HFD + 5×10 8 colony forming units (cfu)/mouse), (4) middle dose-treated group (HFD + 2.5×10 9 cfu/mouse), and (5) high dose-treated group (HFD + 5×10 9 cfu/mouse). Supplementation with the probiotic mixture did not affect plasma alanine aminotransferase and aspartate aminotransferase levels. Probiotic supplementation was decreased body weight gain, plasma lipid levels, and adipose tissue. In addition, mixed probiotics significantly altered the levels of plasma insulin, adiponectin, and leptin. Histological analysis of liver and epididymal adipose tissue also revealed reduced fat deposition and adipocyte size. These results suggest that the probiotic mixture of Bifidobacterium animalis subsp. lactis CP-9 and Lactobacillus rhamnosus bv-77 can alleviate diet-induced obesity and associated diseases by regulating fat accumulation, lipid metabolism, and the levels of leptin and adiponectin.
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