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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 317 - 327 (11page)
- DOI
- 10.7783/KJMCS.2021.29.5.317
이용수
초록· 키워드
오류제보하기
Background: In this study, we evaluated the anti-obesity effects of purified mulberry anthocyanins using PB-600 macroporous resin (RPA), and investigated their effects on the weight of the body, liver, and epididymal white adipose tissue, lipid profiles, and mRNA gene expression for lipid metabolism in high-fat diet (HFD)-induced obese C57BL/6J male mice.
Methods and Results: Four-week-old C57BL/6J mice (n = 12/group) were fed an HFD (HFD group) with RPA (HFD + RPA group, 5,000 ㎎/㎏/day, 761.85 ㎎· cyanidin 3-glucoside equivalent/g) for 12 weeks. Mice fed HFD showed increased body weight, insulin resistance, and serum and hepatic lipid levels. In comparison, the HFD + RPA group showed significantly lower body weight and fat mass with a decreasing food efficiency ratio than the HFD control mice. Additionally, the RPA group showed significantly lower levels of total cholesterol and blood glucose, decreased homeostatic model assessment insulin resistance (HOMA-IR) score, attenuated lipid accumulation, and decreased leptin secretion. Regarding the mRNA expression of genes related to anti-obesity and anti-inflammatory properties, RPA decreased the expression levels of PPARγ, FAS, IL-6, and TNFα, compared to the HFD control, while increased the CPT 1 expression levels increased.
Conclusions: These results confirm that RPA, a purified mulberry anthocyanin has anti-obesity, and anti-inflammatory effects and could be used for functional and health-promoting activities, such as reducing obesity and insulin resistance at high doses in obese animals models.
Methods and Results: Four-week-old C57BL/6J mice (n = 12/group) were fed an HFD (HFD group) with RPA (HFD + RPA group, 5,000 ㎎/㎏/day, 761.85 ㎎· cyanidin 3-glucoside equivalent/g) for 12 weeks. Mice fed HFD showed increased body weight, insulin resistance, and serum and hepatic lipid levels. In comparison, the HFD + RPA group showed significantly lower body weight and fat mass with a decreasing food efficiency ratio than the HFD control mice. Additionally, the RPA group showed significantly lower levels of total cholesterol and blood glucose, decreased homeostatic model assessment insulin resistance (HOMA-IR) score, attenuated lipid accumulation, and decreased leptin secretion. Regarding the mRNA expression of genes related to anti-obesity and anti-inflammatory properties, RPA decreased the expression levels of PPARγ, FAS, IL-6, and TNFα, compared to the HFD control, while increased the CPT 1 expression levels increased.
Conclusions: These results confirm that RPA, a purified mulberry anthocyanin has anti-obesity, and anti-inflammatory effects and could be used for functional and health-promoting activities, such as reducing obesity and insulin resistance at high doses in obese animals models.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFFERENCES
참고문헌 (35)
참고문헌 신청
Akash MSH / 2018 / Tumor necrosis factor-alpha : Role in development of insulin resistance and pathogenesis of type 2 diabetes mellitus / Journal of Cellular Biochemistry 119:105~110
Akhlaghi M / 2018 / Flavanols are potential antiobesity agents, a systematic review and meta-analysis of controlled clinical trials / Nutrition, Metabolism and Cardiovascular Diseases 28:675~690
Alzaid F / 2013 / Regulation of glucose transporter expression in human intestinal Caco-2 Cells following exposure to an anthocyanin-rich berry extract / PLoS ONE 8:e78932
Arçri DP / 2009 / Antiobesity effects of yerba maté extract(Ilex paraguariensis)in high-fat diet-induced obese mice / Obesity 17:2127~2133
Azzini E / 2017 / Antiobesity effects of anthocyanins in preclinical and clinical studies / Oxidative Medicine and Cellular Longevity 2017:2740364
Akhlaghi M / 2018 / Flavanols are potential antiobesity agents, a systematic review and meta-analysis of controlled clinical trials / Nutrition, Metabolism and Cardiovascular Diseases 28:675~690
Alzaid F / 2013 / Regulation of glucose transporter expression in human intestinal Caco-2 Cells following exposure to an anthocyanin-rich berry extract / PLoS ONE 8:e78932
Arçri DP / 2009 / Antiobesity effects of yerba maté extract(Ilex paraguariensis)in high-fat diet-induced obese mice / Obesity 17:2127~2133
Azzini E / 2017 / Antiobesity effects of anthocyanins in preclinical and clinical studies / Oxidative Medicine and Cellular Longevity 2017:2740364
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