지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 773 - 786 (14page)
- DOI
- 10.4093/dmj.2020.0157
이용수
초록· 키워드
오류제보하기
Background: Autophagy maintains muscle mass and healthy skeletal muscles. Several recent studies have associated sugar-sweetened beverage (SSB) consumption with diseases. We investigated whether muscle dysfunction due to obesity could be restored by SSB restriction (SR) alone or in combination with exercise (EX) training.Methods: Obese mice were subjected to SR combined with treadmill EX. Intraperitoneal glucose tolerance test, grip strength test, hanging time test, and body composition analysis were performed. Triglyceride (TG) and total cholesterol (TC) serum concentrations and TG concentrations in quadriceps muscles were analyzed. Western blot and reverse transcription-quantitative polymerase chain reaction helped analyze autophagy-related protein and mRNA expression, respectively.Results: SR alone had no significant effect on fasting blood glucose levels, glucose tolerance, and muscle function. However, it had effect on serum TC, serum TG, and BCL2 interacting protein 3 expression. SR+EX improved glucose tolerance and muscle function and increased serum TC utilization than SR alone. SR+EX reduced P62 levels, increased glucose transporter type 4 and peroxisome proliferator-activated receptor γ coactivator-1α protein expression, and improved grip strength relative to the high-fat and high-sucrose liquid (HFHS) group, and this was not observed in the HFHS+EX group.Conclusion: SR induced mitophagy-related protein expression in quadriceps, without affecting muscle function. And, the combination of SR and EX activated mitophagy-related proteins and improved muscle function.
목차
등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Hruby A / 2015 / The epidemiology of obesity : a big picture / Pharmacoeconomics 33:673~689
De Pergola G / 2013 / Obesity as a major risk factor for cancer / J Obes 2013:291546
Wearing SC / 2006 / Musculoskeletal disorders associated with obesity : a biomechanical perspective / Obes Rev 7:239~250
De Stefano F / 2015 / Obesity, muscular strength, muscle composition and physical performance in an elderly population / J Nutr Health Aging 19:785~791
Collins KH / 2018 / Obesity, metabolic syndrome, and musculoskeletal disease : common inflammatory pathways suggest a central role for loss of muscle integrity / Front Physiol 9:112
De Pergola G / 2013 / Obesity as a major risk factor for cancer / J Obes 2013:291546
Wearing SC / 2006 / Musculoskeletal disorders associated with obesity : a biomechanical perspective / Obes Rev 7:239~250
De Stefano F / 2015 / Obesity, muscular strength, muscle composition and physical performance in an elderly population / J Nutr Health Aging 19:785~791
Collins KH / 2018 / Obesity, metabolic syndrome, and musculoskeletal disease : common inflammatory pathways suggest a central role for loss of muscle integrity / Front Physiol 9:112
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