지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한비만학회 Journal of Obesity & Metabolic Syndrome Journal of Obesity & Metabolic Syndrome Vol.28 No.3
- 발행연도
- 2019.1
- 수록면
- 175 - 185 (11page)
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초록· 키워드
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Background: Autophagy maintains metabolic homeostasis of muscles, and its impairment may cause muscle dysfunction. Exercise can improve muscle dysfunction induced by long-term high-fat diet. This study aimed to explore the association of autophagy with impaired muscle dysfunction in obese conditions and investigate its relationship with exercise-induced muscle function improvement. Methods: Male C57BL/6 mice (n=24) were randomly assigned to four groups: low-fat diet+plain water feeding sedentary (CON) group, low-fat diet+plain water feeding exercise (CON+EX) group, high-fat high-sucrose (HFHS) diet-fed sedentary group, and HFHS diet-fed exercise (HFHS+EX) group, and subjected to a single bout of exhaustive exercise. Results: HFHS diet resulted in shorter hanging time, reduced grip force, and lower exhaustion time and distance, and decreased lean mass per body weight. Moreover, in the soleus, which is chosen as a representative red (oxidative) muscle, LC3II/LC3I ratio, P62, and Bnip3 levels were altered following the HFHS diet, and were negatively correlated with muscle performance parameters; exercise significantly decreased the LC3II/LC3 ratio while P62 increased with HFHS diet. Autophagy-related protein changes were not found in the white (glycolytic) gastrocnemius. Conclusion: The study revealed that 20-week HFHS diet causes a significant increase in body weight and fat mass, along with a decrease in muscle function. Autophagy-related LC3 and P62 protein expression was negatively correlated with muscle function, and they were reduced when a single bout of exercise stimulated the soleus of obese mice. However, no change of autophagy-related proteins was seen in the gastrocnemius.
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참고문헌 (39)
참고문헌 신청
Martinson M / 2014 / Associations of body size and body composition with functional ability and quality of life in hemodialysis patients / Clin J Am Soc Nephrol 9:1082~1090
Yang ZH / 2012 / Diet high in fat and sucrose induces rapid onset of obesity-related metabolic syndrome partly through rapid response of genes involved in lipogenesis, insulin signalling and inflammation in mice / Diabetol Metab Syndr 4:32
Dandona P / 2004 / Inflammation: the link between insulin resistance, obesity and diabetes / Trends Immunol 25:4~7
Ostler JE / 2014 / Effects of insulin resistance on skeletal muscle growth and exercise capacity in type 2 diabetic mouse models / Am J Physiol Endocrinol Metab 306:E592~E605
Lee SR / 2015 / Effects of chronic high-fat feeding on skeletal muscle mass and function in middle-aged mice / Aging Clin Exp Res 27:403~411
Yang ZH / 2012 / Diet high in fat and sucrose induces rapid onset of obesity-related metabolic syndrome partly through rapid response of genes involved in lipogenesis, insulin signalling and inflammation in mice / Diabetol Metab Syndr 4:32
Dandona P / 2004 / Inflammation: the link between insulin resistance, obesity and diabetes / Trends Immunol 25:4~7
Ostler JE / 2014 / Effects of insulin resistance on skeletal muscle growth and exercise capacity in type 2 diabetic mouse models / Am J Physiol Endocrinol Metab 306:E592~E605
Lee SR / 2015 / Effects of chronic high-fat feeding on skeletal muscle mass and function in middle-aged mice / Aging Clin Exp Res 27:403~411
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