High Incidence of Chronic Kidney Disease among Iranian Diabetic Adults: Using CKD-EPI and MDRD Equations for Estimated Glomerular Filtration Rate

Seyyed Saeed Moazzeni; Reyhane Hizomi Arani; Mitra Hasheminia; Maryam Tohidi; Fereidoun Azizi; Farzad Hadaegh

doi:10.4093/dmj.2020.0109

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자료유형: 학술저널

저자정보: Seyyed Saeed Moazzeni (Shahid Beheshti University of Medical Sciences) Reyhane Hizomi Arani (Shahid Beheshti University of Medical Sciences) Mitra Hasheminia (Shahid Beheshti University of Medical Sciences) Maryam Tohidi (Shahid Beheshti University of Medical Sciences) Fereidoun Azizi (Shahid Beheshti University of Medical Sciences) Farzad Hadaegh (Shahid Beheshti University of Medical Sciences)

저널정보: 대한당뇨병학회 Diabetes and Metabolism Journal Diabetes and Metabolism Journal Vol.45 No.5

발행연도: 2021.9

수록면: 684 - 697 (14page)

DOI: 10.4093/dmj.2020.0109

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Background: To investigate the population based incidence rate of chronic kidney disease (CKD) and its potential risk factors among Iranian diabetic adults during over 14 years of follow-up.Methods: Two different equations (Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] and Modification of Diet in Renal Disease [MDRD]) were applied for the calculating the estimated glomerular filtration rate (eGFR). Among a total of 1,374 diabetic Tehranian adults, 797 and 680 individuals were eligible for CKD-EPI and MDRD analyses, respectively. CKD was defined as eGFR lower than 60 mL/min/1.73 m2. Multivariable Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CI) for all potential risk factors.Results: The incidence rates (95% CI) of CKD per 1,000 person-years were 43.84 (39.49 to 48.66) and 55.80 (50.29 to 61.91) based on CKD-EPI and MDRD equations, respectively. Being older, a history of cardiovascular disease, and having lower levels of eGFR were significant risk factors in both equations. Moreover, in CKD-EPI, using glucose-lowering medications and hypertension, and in MDRD, female sex and fasting plasma glucose ≥10 mmol/L were also independent risk factors. Regarding the discrimination index, CKD-EPI equation showed a higher range of C-index for the predicted probability of incident CKD in the full-adjusted model, compared to MDRD equation (0.75 [0.72 to 0.77] vs. 0.69 [0.66 to 0.72]).Conclusion: We found an incidence rate of more than 4%/year for CKD development among our Iranian diabetic population. Compared to MDRD, it can be suggested that CKD-EPI equation can be a better choice to use for prediction models of incident CKD among the Iranian diabetic populations.

#Diabetes mellitus #Glomerular filtration rate #Incidence #Iran #Renal insufficiency #chronic #Risk factors

참고문헌 (50)

참고문헌 신청

Hill NR / 2016 / Global prevalence of chronic kidney disease : a systematic review and meta-analysis / PLoS One 11:e0158765

Mills KT / 2015 / A systematic analysis of worldwide population-based data on the global burden of chronic kidney disease in 2010 / Kidney Int 88:950~957

Tohidi M / 2012 / Incidence of chronic kidney disease and its risk factors, results of over 10 year follow up in an Iranian cohort / PLoS One 7:e45304

Esteghamati A / 2014 / Trends in the prevalence of diabetes and impaired fasting glucose in association with obesity in Iran : 2005-2011 / Diabetes Res Clin Pract 103:319~327

Shen Y / 2017 / Diabetes mellitus as a risk factor for incident chronic kidney disease and end-stage renal disease in women compared with men : a systematic review and meta-analysis / Endocrine 55:66~76

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