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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제14권 제4호
- 발행연도
- 2016.1
- 수록면
- 345 - 350 (6page)
이용수
초록· 키워드
오류제보하기
Objective: Human serum paraoxonase (PON1) prevents lipids from peroxidation and functions as an antioxidant mechanism.
Malonyldialdehyde (MDA) is the final product of lipid peroxidation and can be used as an indicator of oxidative stress. The aim of this study was to investigate PON1, MDA, and arylesterase (ARY) levels in schizophrenic patients who are taking typical, atypical, or combined (typical and atypical) antipsychotic drug treatment, with respect to those of healthy controls.
Methods: We evaluated 41 patients (11 taking typical antipsychotics, 19 taking atypical antipsychotics, 11 taking combined antipsychotics) and 43 healthy controls.
Results: MDA levels were higher in schizophrenic patients taking typical antipsychotics compared with healthy controls (p=0.001).
ARY levels were higher in patients taking atypical antipsychotics compared with healthy controls (p=0.005). PON1 activity was similar in all groups.
Conclusion: Our results indicate that treatment with typical antipsychotic drugs could be related to increased MDA levels; and antipsychotic medication may increase PON1 levels in schizophrenic patients.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
노대영 / 2015 / Antipsychotic Prescribing Patterns in First-episode Schizophrenia: A Five-year Comparison / Clinical Psychopharmacology and Neuroscience 13(3):275~282
Ganesan Venkatasubramanian / 2015 / Understanding Schizophrenia as a Disorder of Consciousness: Biological Correlates and Translational Implications from Quantum Theory Perspectives / Clinical Psychopharmacology and Neuroscience 13(1):36~47
Lan-Ting Lee / 2015 / Holistic Consideration of Patients with Schizophrenia to Improve Medication Adherence and Outcomes / Clinical Psychopharmacology and Neuroscience 13(2):138~143
김성진 / 2015 / The Relationship between Language Ability and Cognitive Function in Patients with Schizophrenia / Clinical Psychopharmacology and Neuroscience 13(3):288~295
Anupa A. Vijayakumari / 2015 / Effect of Polymorphisms of Three Genes Mediating Monoamine Signalling on Brain Morphometry in Schizophrenia and Healthy Subjects / Clinical Psychopharmacology and Neuroscience 13(1):68~82
Ganesan Venkatasubramanian / 2015 / Understanding Schizophrenia as a Disorder of Consciousness: Biological Correlates and Translational Implications from Quantum Theory Perspectives / Clinical Psychopharmacology and Neuroscience 13(1):36~47
Lan-Ting Lee / 2015 / Holistic Consideration of Patients with Schizophrenia to Improve Medication Adherence and Outcomes / Clinical Psychopharmacology and Neuroscience 13(2):138~143
김성진 / 2015 / The Relationship between Language Ability and Cognitive Function in Patients with Schizophrenia / Clinical Psychopharmacology and Neuroscience 13(3):288~295
Anupa A. Vijayakumari / 2015 / Effect of Polymorphisms of Three Genes Mediating Monoamine Signalling on Brain Morphometry in Schizophrenia and Healthy Subjects / Clinical Psychopharmacology and Neuroscience 13(1):68~82
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