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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 505 - 515 (11page)
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Human pluripotent stem cells (hPSCs) include human embryonic stem cells (hESCs) derived from blastocysts and human induced pluripotent stem cells (hiPSCs) generated from somatic cell reprogramming. Due to their self-renewal ability and pluripotent differentiation potential, hPSCs serve as an excellent experimental platform for human development, disease modeling, drug screening, and cell therapy. Traditionally, hPSCs were considered to form a homogenous population. However, recent advances in single cell technologies revealed a high degree of variability between individual cells within a hPSC population. Different types of heterogeneity can arise by genetic and epigenetic abnormalities associated with long-term in vitro culture and somatic cell reprogramming. These variations initially appear in a rare population of cells. However, some cancer-related variations can confer growth advantages to the affected cells and alter cellular phenotypes, which raises significant concerns in hPSC applications. In contrast, other types of heterogeneity are related to intrinsic features of hPSCs such as asynchronous cell cycle and spatial asymmetry in cell adhesion. A growing body of evidence suggests that hPSCs exploit the intrinsic heterogeneity to produce multiple lineages during differentiation. This idea offers a new concept of pluripotency with single cell heterogeneity as an integral element. Collectively, single cell heterogeneity is Janus-faced in hPSC function and application. Harmful heterogeneity has to be minimized by improving culture conditions and screening methods. However, other heterogeneity that is integral for pluripotency can be utilized to control hPSC proliferation and differentiation.
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참고문헌 (110)
참고문헌 신청
Nichols J / 2009 / Naive and primed pluripotent states / Cell Stem Cell 4:487~492
Weinberger L / 2016 / Dynamic stem cell states : naive to primed pluripotency in rodents and humans / Nat Rev Mol Cell Biol 17:155~169
Niwa H / 2009 / A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells / Nature 460:118~122
Toyooka Y / 2008 / Identification and characterization of subpopulations in undifferentiated ES cell culture / Development 135:909~918
Wang J / 2014 / Primate-specific endogenous retrovirus-driven transcription defines naivelike stem cells / Nature 516:405~409
Weinberger L / 2016 / Dynamic stem cell states : naive to primed pluripotency in rodents and humans / Nat Rev Mol Cell Biol 17:155~169
Niwa H / 2009 / A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells / Nature 460:118~122
Toyooka Y / 2008 / Identification and characterization of subpopulations in undifferentiated ES cell culture / Development 135:909~918
Wang J / 2014 / Primate-specific endogenous retrovirus-driven transcription defines naivelike stem cells / Nature 516:405~409
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