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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 643 - 652 (10page)
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Recent advances in stem cell biology have dramatically increased the understanding of molecular and cellular mechanism of pluripotency and cell fate determination. Additionally, pluripotent stem cells (PSCs), including embryonic stem cells and induced pluripotent stem cells, arose as essential resources for disease modeling and cellular therapeutics. Despite these advancements, the epigenetic dysregulation in pluripotency such as the imprinting status, and X chromosome dosage compensation, and its consequences on future utility of PSCs yet remain unresolved. In this review, we will focus on the X chromosome regulation in human PSCs (hPSCs). We will introduce the previous findings in the dosage compensation process on mouse model, and make comparison with those of human systems. Particularly, the X chromosome activation status of human preimplantation embryos, and the regulation of the active X chromosome by human specific lincRNA, X Active Coating Transcript (XACT), will be discussed. We will also discuss the recent findings on higher order X chromosome architecture, and abnormal X chromosome status in hPSCs.
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등록된 정보가 없습니다.
참고문헌 (4)
참고문헌 신청
Stadtfeld M / 2008 / Induced pluripotent stem cells generated without viral integration / Science 322(5903):945~949
정재민 / 2016 / Functional Comparison of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells as Sources of Hepatocyte-Like Cells / 조직공학과 재생의학 13(6):740~749
홍권호 / 2015 / Cellular Reprogramming and Its Application in Regenerative Medicine / 조직공학과 재생의학 12(2):80~89
Marahrens Y / 1997 / Xist-deficient mice are defective in dosage compensation but not spermatogenesis / Genes Dev 11(2):156~166
정재민 / 2016 / Functional Comparison of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells as Sources of Hepatocyte-Like Cells / 조직공학과 재생의학 13(6):740~749
홍권호 / 2015 / Cellular Reprogramming and Its Application in Regenerative Medicine / 조직공학과 재생의학 12(2):80~89
Marahrens Y / 1997 / Xist-deficient mice are defective in dosage compensation but not spermatogenesis / Genes Dev 11(2):156~166
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