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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 323 - 328 (6page)
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Lysophosphatidylcholine (LPC) is a major phospholipid component of oxidized low-density lipoprotein (ox-LDL) and is implicated in its atherogenic activity. This study investigated the effects of LPC on cell viability, intracellular calcium homeostasis, and the protective mechanisms of chlorogenic acid (CGA) in human umbilical vein endothelial cells (HUVECs). LPC increased intracellular calcium ([Ca2＋]i) by releasing Ca2＋ from intracellular stores and via Ca2＋ influx through store-operated channels (SOCs). LPC also increased the generation of reactive oxygen species (ROS) and decreased cell viability. The mRNA expression of Transient receptor potential canonical (TRPC) channel 1 was increased significantly by LPC treatment and suppressed by CGA. CGA inhibited LPC-induced Ca2＋ influx and ROS generation, and restored cell viability. These results suggested that CGA inhibits SOC-mediated Ca2＋ influx and ROS generation by attenuating TRPC1 expression in LPC-treated HUVECs. Therefore, CGA might protect endothelial cells against LPC injury, thereby inhibiting atherosclerosis.
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등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Grandl M / 2010 / Fluorescent high-content imaging allows the discrimination and quantitation of E-LDL-induced lipid droplets and Ox-LDL-generated phospholipidosis in human macrophages / Cytometry A 77:231~242
Steinbacher P / 2015 / Impact of oxidative stress on exercising skeletal muscle / Biomolecules 5:356~377
Fedrizzi L / 2008 / Calcium and signal transduction / Biochem Mol Biol Educ 36:175~180
Brini M / 2013 / Intracellular calcium homeostasis and signaling / Met Ions Life Sci 12:119~168
Korkiamaki T / 2005 / The effect of extracellular calcium concentration on calciummediated cell signaling in NF1 tumor suppressor-deficient keratinocytes / Arch Dermatol Res 296:465~472
Steinbacher P / 2015 / Impact of oxidative stress on exercising skeletal muscle / Biomolecules 5:356~377
Fedrizzi L / 2008 / Calcium and signal transduction / Biochem Mol Biol Educ 36:175~180
Brini M / 2013 / Intracellular calcium homeostasis and signaling / Met Ions Life Sci 12:119~168
Korkiamaki T / 2005 / The effect of extracellular calcium concentration on calciummediated cell signaling in NF1 tumor suppressor-deficient keratinocytes / Arch Dermatol Res 296:465~472
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