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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 203 - 208 (6page)
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초록· 키워드
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Lysophosphatidylcholine (LPC) is a bioactive lysolipid known to contribute to the development of lung allergic diseases. However, it remains unknown whether LPC possesses proinflammatory properties in the skin as well. Here, we investigated this issue by injection of LPC into the murine contact hypersensitivity (CHS) model induced by 2,4-dinitrofluorobenzene (DNFB). LPC increased the expression of IL17, recruited more neutrophils, and eventually aggravated the CHS in the skins. Moreover, the effects of LPC diminished after neutralizing IL17 or depleting neutrophils. Mechanistically, LPC upregulated not only IL17 but also CXCL1 and CXCL2 in a G2A-dependent manner. Taken together, our study demonstrated that the upregulation of LPC could contribute to allergic skin inflammation by increasing IL17 expression and neutrophil recruitment via G2A receptor.
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등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Kaplan DH / 2012 / Early immune events in the induction of allergic contact dermatitis / Nat Rev Immunol 12:114~124
Honda T / 2013 / Update of immune events in the murine contact hypersensitivity model : toward the understanding of allergic contact dermatitis / J Invest Dermatol 133:303~315
Weber FC / 2015 / Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity / J Exp Med 212:15~22
Rafei-Shamsabadi DA / 2018 / Lack of type 2 innate lymphoid cells promotes a type I-driven increased immune response in contact hypersensitivity / J Invest Dermatol 138:1962~1972
Jiang X / 2017 / Dermal gammadelta T cells do not freely re-circulate out of skin and produce IL-17 to promote neutrophil infiltration during primary contact hypersensitivity / PLoS One 12:e0169397
Honda T / 2013 / Update of immune events in the murine contact hypersensitivity model : toward the understanding of allergic contact dermatitis / J Invest Dermatol 133:303~315
Weber FC / 2015 / Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity / J Exp Med 212:15~22
Rafei-Shamsabadi DA / 2018 / Lack of type 2 innate lymphoid cells promotes a type I-driven increased immune response in contact hypersensitivity / J Invest Dermatol 138:1962~1972
Jiang X / 2017 / Dermal gammadelta T cells do not freely re-circulate out of skin and produce IL-17 to promote neutrophil infiltration during primary contact hypersensitivity / PLoS One 12:e0169397
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