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학술저널
저자정보
이민형 (동국대학교) 길현민 (동국대학교 산학기술협력센터) Eugene Cheon (동국대학교) 김소연 (동국대학교) Jeahee Ryu (동국대학교) Hayoung Khil (동국대학교) 강충원 (동국대학교) 박승일 (동국대학교) 강석성 (동국대학교) 금나나 (동국대학교) 권영은 (동국대학교)
저널정보
한국바이오칩학회 BioChip Journal BioChip Journal Vol.15 No.3
발행연도
2021.9
수록면
296 - 304 (9page)
DOI
10.1007/s13206-021-00028-x

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Food sensitivity is considered to be implicated in obesity via chronic inflammation. Obesity has become a global epidemic, and overweight is a gateway to obesity. Hence, understanding the effect of food sensitivity on overweight is important for public health. To examine the association between food sensitivity and overweight, we compared the levels of diverse serological IgGs (total IgG, food-specific IgG [sIgG], and total food-sIgG [the sum of food-sIgG]) between overweight and lean Korean adults. A total of 164 Koreans aged 19?29 years participated in the study. We collected serum samples, information on frequency of food consumption, and height and weight measures to calculate body mass index (BMI). Immunoassays were performed using protein microarrays to determine total IgG, food-sIgG for each of the 68 food antigens, and the total food-sIgG. Participants were classified as overweight (BMI ≥ 25 kg/m 2 ) or lean (BMI < 25 kg/m 2 ). The Wilcoxon rank-sum test was used to compare the decile scores of IgG values between the groups. The total IgG ( P = 0.58) and total food-sIgG scores ( P = 0.27) did not differ significantly between the groups, precluding chronic inflammation as the cause of overweight. However, in the overweight group, food-sIgG scores against dairy products and seafood were significantly higher ( P < 0.05), whereas those against fruit and vegetables were significantly lower ( P < 0.05). In overweight individuals, food-sIgG scores against milk were not associated with the actual consumption ( P = 0.76), suggesting higher food-sIgG as an indicator of higher sensitivity than of higher consumption. Higher sensitivity to dairy foods and seafood and lower sensitivity to fruit and vegetables are likely associated with weight gain. Future studies are warranted to understand the heterogeneous associations between food-sIgGs and overweight.

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