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자료유형
학술저널
저자정보
Jong Hyeon Jeong (Departments of Internal Medicine Konkuk University School of Medicine) 이선영 (건국대학교) Hye Seung Han (Department of Pathology Konkuk University School of Medicine Seoul Korea.) Jeong Hwan Kim (Departments of Internal Medicine Konkuk University School of Medicine) In-Kyung Sung (Department of Internal Medicine Konkuk University School of Medicine) Hyung Seok Park (Department of Internal Medicine Konkuk University School of Medicine Seoul Korea)
저널정보
대한상부위장관 헬리코박터학회 Korean Journal of Helicobacter Upper Gastrointestinal Research Korean Journal of Helicobacter Upper Gastrointestinal Research Vol.21 No.3
발행연도
2021.9
수록면
226 - 234 (9page)
DOI
https://doi.org/10.7704/kjhugr.2021.0016

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Autoimmune gastritis is a corpus-dominant type of gastritis with positive serum anti-parietal cell antibodies (APCA) and/or anti-intrinsic factor antibodies. Serum APCA and pepsinogen (PG) assays were performed in subjects with corpus-dominant gastritis detected by endoscopy. Serum APCA was positive in five patients. All these patients were postmenopausal women (four Koreans and one Caucasian from the Russian Federation) with a mean age of 59.0±3.2 years. They displayed low PG I levels ranging from 8.1 to 18.8 ng/mL (mean, 11.4±4.8 ng/mL) and low PG I/II ratios ranging from 0.7 to 2.4 (mean, 1.2±0.7). Three of the patients were being treated for autoimmune thyroiditis. Multiple gastric neuroendocrine tumors were observed in two Helicobacter pylori (H. pylori)- naive patients with high serum gastrin levels exceeding 700 pg/mL and serum chromogranin A levels exceeding 1,000 ng/mL. In the remaining three patients, intestinal metaplasia was observed in the biopsied specimens from the antrum, suggesting a history of H. pylori infection. Our findings indicate the value of positive serum APCA findings, low serum PG I levels, and low serum PG I/II ratios in confirming autoimmune gastritis in patients showing corpus-dominant atrophy, regardless of their H. pylori infection status.

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