지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 941 - 951 (11page)
- DOI
- 10.1007/s13770-021-00377-6
이용수
초록· 키워드
오류제보하기
Background: We aimed to validate a pilot study of photodiagnosis using near infrared (NIR) transillumination and assess the clinical efficacy of hypericin-mediated photodynamic therapy (HYP-PDT) in a rabbit laryngeal cancer model in order to develop a novel therapeutic modality with complete remission and preservation of the functional organ.
Methods: (1) In vitro study: VX tumor cells were subcultured and subjected to HYP-PDT. (2) In vivo study: A laryngeal cancer model was developed in which 12 rabbits were inoculated with a VX tumor suspension in the submucosal area of the left vocal fold using a transoral approach. All rabbits underwent NIR transillumination using light with a wavelength of 780 nm. The survival periods of the three treatment groups (6 rabbits in Group A: HYP-PDT, 3 each in Groups B and C: laser irradiation or HYP administration only) were analyzed.
Results: The higher the HYP concentration, the lower the VX cell viability in response to HYP-PDT using 590 nm LED. Following HYP-PDT, small tumors in Group A-1 rabbits healed completely and the animals demonstrated a long survival period, and larger tumors in Group A-2 healed partially with a survival period that extended over 3 weeks after inoculation. The survival of Groups B and C were not different over the first 3 weeks of the study, and were shorter than in Group A.
Conclusion: We found HYP-PDT could be a curative therapy for early-stage cancers that may also preserve organ function, and may inhibit tumor progression and metastasis during advanced stages of laryngeal cancer.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Nakayama M / 2012 / Functional organ preservation for laryngeal cancer : past, present and future / Jpn J Clin Oncol 42:155~160
von Beckerath MP / 2014 / Outcome of primary treatment of early laryngeal malignancies using photodynamic therapy / Acta Otolaryngol 134:852~858
최정석 / 2020 / Hyaluronic Acid/Alginate Hydrogel Containing Hepatocyte Growth Factor and Promotion of Vocal Fold Wound Healing / 조직공학과 재생의학 17(5):651~658
Jung Soo Yeon / 2020 / Development of Acellular Respiratory Mucosal Matrix Using Porcine Tracheal Mucosa / 조직공학과 재생의학 17(4):433~443
Xin Zhou / 2021 / Investigation of the Clinical Potential of Polarization-Sensitive Optical Coherence Tomography in a Laryngeal Tumor Model / 조직공학과 재생의학 18(1):81~87
von Beckerath MP / 2014 / Outcome of primary treatment of early laryngeal malignancies using photodynamic therapy / Acta Otolaryngol 134:852~858
최정석 / 2020 / Hyaluronic Acid/Alginate Hydrogel Containing Hepatocyte Growth Factor and Promotion of Vocal Fold Wound Healing / 조직공학과 재생의학 17(5):651~658
Jung Soo Yeon / 2020 / Development of Acellular Respiratory Mucosal Matrix Using Porcine Tracheal Mucosa / 조직공학과 재생의학 17(4):433~443
Xin Zhou / 2021 / Investigation of the Clinical Potential of Polarization-Sensitive Optical Coherence Tomography in a Laryngeal Tumor Model / 조직공학과 재생의학 18(1):81~87
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