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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 651 - 658 (8page)
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초록· 키워드
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Background: Hepatocyte growth factor (HGF) has been shown to facilitate vocal fold (VF) wound healing. This study was undertaken to determine whether the therapeutic efficacy of HGF could be enhanced by applying it in hyaluronic acid and alginate (HA/ALG) composite hydrogels into VFs after injury in a rabbit model. Methods: HGF was loaded into HA/ALG composite hydrogel (HGF–HA/ALG) and its in vitro release profile was evaluated. In addition, HGF–HA/ALG was injected into the VFs of rabbits immediately after direct injury and HGF or PBS was injected in the same manner into control groups. Macroscopic features were observed by endoscopy at 3 months post-injury. Functional analyses including mucosal waves of VFs and viscoelastic properties were performed by kymography following high-speed digital imaging and rheometer. Histopathological and immunohistochemical evaluations were also conducted on VFs. Results: HGF release from HGF–HA/ALG was sustained for up to 3 weeks. Rabbits treated with HGF–HA/ALG showed improved mucosal vibrations and VF viscoelastic properties as compared with the PBS and HGF controls. Histopathological staining revealed HGF–HA/ALG treated VFs showed less fibrosis than PBS and HGF controls, and immunohistochemical analysis demonstrated amounts of type I collagen and fibronectin were lower in HGF–HA/ALG treated animals than in PBS and HGF controls at 3 months post-injury. Conclusion: HGF containing HA/ALG hydrogel enhanced healing in our rabbit model of VF injury.
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참고문헌 (32)
참고문헌 신청
Choi JS / 2015 / Functional remodeling after vocal fold injury by small intestinal submucosa gel containing hepatocyte growth factor / Biomaterials 40:98~106
Hansen JK / 2006 / Current understanding and review of the literature : vocal fold scarring / J Voice 20:110~120
우승훈 / 2014 / Prevalence of Laryngeal Disease in South Korea: Data from the Korea National Health and Nutrition Examination Survey from 2008 to 2011 / Yonsei Medical Journal 55(2):499~507
Long JL / 2010 / Tissue engineering for treatment of vocal fold scar / Curr Opin Otolaryngol Head Neck Surg 18:521~525
Hirano S / 2004 / Prevention of vocal fold scarring by topical injection of hepatocyte growth factor in a rabbit model / Laryngoscope 114:548~556
Hansen JK / 2006 / Current understanding and review of the literature : vocal fold scarring / J Voice 20:110~120
우승훈 / 2014 / Prevalence of Laryngeal Disease in South Korea: Data from the Korea National Health and Nutrition Examination Survey from 2008 to 2011 / Yonsei Medical Journal 55(2):499~507
Long JL / 2010 / Tissue engineering for treatment of vocal fold scar / Curr Opin Otolaryngol Head Neck Surg 18:521~525
Hirano S / 2004 / Prevention of vocal fold scarring by topical injection of hepatocyte growth factor in a rabbit model / Laryngoscope 114:548~556
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