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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 864 - 870 (7page)
- DOI
- 10.30773/pi.2021.0104
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초록· 키워드
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Objective Due to high cost of amyloid imaging, its use of amyloid imaging to confirm amyloid pathology is limited in clinical practice. It is of importance to develop a model to predict cerebral amyloid positivity using clinical data obtained from a memory clinic.Methods A total of 410 participants who had symptom of subjective cognitive decline and underwent amyloid PET and apolipoprotein ε (APOE) genotyping were retrospectively enrolled from January 2016 to January 2019. Models for cerebral amyloid positivity prediction were developed in all subjects, mild cognitive impairment (MCI) subjects, and Alzheimer’s disease (AD) dementia subjects through multivariate logistic regression analysis. The performance of the models was assessed using receiver operating characteristic (ROC) curve analysis and the area under the curve (AUC) values.Results Age, sex, years of education, body mass index (BMI), APOE4, and mini mental state examination score (MMSE) were selected for the final model for all subjects. The AUC value of the ROC curve was 0.775. Age, sex, years of education, BMI, and APOE4 were selected for the final model for MCI subjects. The AUC value was 0.735. Age, sex, years of education, BMI, APOE4, MMSE, and history of hypertension were selected for the final model for AD dementia subjects. The AUC value was 0.845.Conclusion This study found that models using clinical data can predict cerebral amyloid positivity according to cognitive status. These models can be useful as a screening tool predict cerebral amyloid deposition in cognitively impaired patients in a memory clinic.
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참고문헌 (28)
참고문헌 신청
Alzheimer’s Association / 2013 / 2013 Alzheimer’s disease facts and figures / Alzheimers Dement 9:208~245
Bateman RJ / 2012 / Clinical and biomarker changes in dominantly inherited Alzheimer’s disease / N Engl J Med 367:795~804
Beach TG / 2012 / Accuracy of the clinical diagnosis of Alzheimer disease at National Institute on Aging Alzheimer Disease Centers, 2005-2010 / J Neuropathol Exp Neurol 71:266~273
Ossenkoppele R / 2013 / Impact of molecular imaging on the diagnostic process in a memory clinic / Alzheimers Dement 9:414~421
Johnson KA / 2013 / Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer’s Association / Alzheimers Dement 9:1~16
Bateman RJ / 2012 / Clinical and biomarker changes in dominantly inherited Alzheimer’s disease / N Engl J Med 367:795~804
Beach TG / 2012 / Accuracy of the clinical diagnosis of Alzheimer disease at National Institute on Aging Alzheimer Disease Centers, 2005-2010 / J Neuropathol Exp Neurol 71:266~273
Ossenkoppele R / 2013 / Impact of molecular imaging on the diagnostic process in a memory clinic / Alzheimers Dement 9:414~421
Johnson KA / 2013 / Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer’s Association / Alzheimers Dement 9:1~16
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