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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 420 - 426 (7page)
- DOI
- https://doi.org/10.4306/pi.2017.14.4.420
이용수
초록· 키워드
오류제보하기
Objective: This study aimed to examine the usefulness of each subscale score of the Clinical Dementia Rating (CDR) for predicting Alzheimer’s disease (AD) dementia progression in amnestic mild cognitive impairment (MCI) elderly subjects.
Methods: Fifty-nine elderly MCI individuals were recruited from a university dementia and memory disorder clinic. Standardized clinical and neuropsychological tests were performed both at baseline and at the time of 2 years follow-up. Logistic regression analyses were conducted to examine the ability of various clinical measures or their combinations to predict progression to AD dementia in MCI individuals.
Results: MCIp individuals showed significantly higher CDR Orientation subscale and CDR sum-of-boxes (SOB) score than MCInp ones, while there were no significant differences in other CDR subscale scores between the two. MCIp individuals also showed marginally higher MMSE scores than MCInp ones. A series of logistic regression analyses demonstrated that the model including CDR Orientation subscale had better AD dementia prediction accuracy than either the model with either MMSE or CDR-SOB.
Conclusion: Our findings suggest that CDR Orientation subscale score, a simple and easily available clinical measure, could provide very useful information to predict AD dementia progression in amnestic MCI individuals in real clinical settings.
목차
등록된 정보가 없습니다.
참고문헌 (50)
참고문헌 신청
Petersen RC / 1999 / Mild cognitive impairment : clinical characterization and outcome / Arch Neurol 56:303~308
Grundman M / 2004 / Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials / Arch Neurol 61:59~66
Gomar JJ / 2011 / Alzheimer’s Disease Neuroimaging Initiative. Utility of combinations of biomarkers, cognitive markers, and risk factors to predict conversion from mild cognitive impairment to Alzheimer disease in patients in the Alzheimer’s disease neuroimaging initiative / Arch Gen Psychiatry 68:961~969
Petersen RC / 2004 / Mild cognitive impairment as a diagnostic entity / J Intern Med 256:183~194
Palmer K / 2008 / Mild cognitive impairment in the general population : occurrence and progression to Alzheimer disease / Am J Geriatr Psychiatry 16:603~611
Grundman M / 2004 / Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials / Arch Neurol 61:59~66
Gomar JJ / 2011 / Alzheimer’s Disease Neuroimaging Initiative. Utility of combinations of biomarkers, cognitive markers, and risk factors to predict conversion from mild cognitive impairment to Alzheimer disease in patients in the Alzheimer’s disease neuroimaging initiative / Arch Gen Psychiatry 68:961~969
Petersen RC / 2004 / Mild cognitive impairment as a diagnostic entity / J Intern Med 256:183~194
Palmer K / 2008 / Mild cognitive impairment in the general population : occurrence and progression to Alzheimer disease / Am J Geriatr Psychiatry 16:603~611
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