Aberrant Effective Connectivity of the Ventral Putamen in Boys With Attention-Deficit/Hyperactivity Disorder

Zhihui Lan; Yunkai Sun; Lei Zhao; Yang Xiao; Changxiao Kuai; Shao-Wei Xue

doi:10.30773/pi.2020.0422

추천

검색

자료유형: 학술저널

저자정보: Zhihui Lan (Center for Cognition and Brain Disorders the Affiliated Hospital Hangzhou Normal University) Yunkai Sun (Center for Cognition and Brain Disorders the Affiliated Hospital Hangzhou Normal University) Lei Zhao (Center for Cognition and Brain Disorders the Affiliated Hospital Hangzhou Normal University) Yang Xiao (Center for Cognition and Brain Disorders the Affiliated Hospital Hangzhou Normal University) Changxiao Kuai (Center for Cognition and Brain Disorders the Affiliated Hospital Hangzhou Normal University) Shao-Wei Xue (Center for Cognition and Brain Disorders the Affiliated Hospital Hangzhou Normal University)

저널정보: 대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제18권 제8호

발행연도: 2021.8

수록면: 763 - 769 (7page)

DOI: 10.30773/pi.2020.0422

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Objective The connectivity alterations in the putamen were found in revealing the neural correlates of attention-deficit/hyperactivity disorder (ADHD), but whether the effective connectivity of the putamen is atypical in ADHD remains unclear. Investigating this abnormality contributes to describing the neural circuit of ADHD at the level of macrostructural organization.Methods Data were acquired from thirty-two boys with ADHD and fifty-two matched typically developing controls (TDC) from Peking University (Peking) dataset deposited at the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) platform. We examined the effective connectivity of the putamen using Granger causality analysis (GCA) and then determined whether these connections could differentiate ADHD from TDC.Results Compared with TDC, the ADHD group showed decreased effective connectivity from the left ventral rostral putamen (VRP) to left calcarine (CAL), right medial part of the superior frontal gyrus, left orbital part of superior frontal gyrus and left middle occipital gyrus (MOG). Increased effective connectivity from the left inferior occipital gyrus and right lingual gyrus to left VRP was also found in ADHD. The result of the classification accuracy showed that 72.3% of participants were correctly classified using support vector machine. Moreover, GCA values from the left VRP to left CAL and left MOG were significantly correlated with hyper/impulsive scores of patients with ADHD.Conclusion The findings may help extend our understanding of the ADHD-related neural loops.

#Attention-deficit/hyperactivity disorder #Effective connectivity #Granger causality analysis #Ventral putamen.

참고문헌 (2)

참고문헌 신청

Junha Park / 2020 / Functional Connectivity of the Striatum as a Neural Correlate of Symptom Severity in Patient with Obsessive-Compulsive Disorder / PSYCHIATRY INVESTIGATION 17(2):87~95

Díaz-Heijtz R / 2002 / Biochemical bases and research in attention-deficit hyperactivity disorder / Rev Neurol 34(Suppl 1):S78~S81

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!