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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 86 - 97 (12page)
- DOI
- 10.1186/s40824-017-0094-6
이용수
초록· 키워드
오류제보하기
Background: The objective of this study was to investigate the in vivo effect of bioactive composites with poly(lactic acid) (PLA) or polycaprolactone (PCL) as the matrix, reinforced with bioplastic flax fibers, on the surrounding muscle tissue. Methods: Materials of pure PLA and PCL and their composites with flax fibers from genetically modified plants producing poly-3-hydroxybutyrate (PLA-transgen, PCL-transgen) and unmodified plants (PLA-wt, PCL-wt) were placed subcutaneous on the M. latissimus dorsi for four weeks. Results: The analysis of histological samples revealed that every tested material was differently encapsulated and the capsule thickness is much more pronounced when using the PCL composites in comparison with the PLA composites. The encapsulation by connective tissue was significantly reduced around PCL-transgen and significantly increased in the cases of PLA-transgen and PLA-wt. In the collected muscle samples, the measured protein expression of CD45, lymphocyte common antigen, was significantly increased after the use of all tested materials, with the exception of pure PCL. In contrast, the protein expression of caveolin-1 remained unchanged after treatment with the most examined materials. Only after insertion of PLA-wt, a significant increase of caveolin-1 protein expression was detected, due to the improved neovascularization. Conclusion: These data support the presumption that the new bioactive composites are biocompatible and they could be applicable in the medical field to support the regenerative processes.
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등록된 정보가 없습니다.
참고문헌 (70)
참고문헌 신청
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Agarwal R / 2015 / Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair / Adv Drug Deliv Rev 94:53~62
Giannoudis PV / 2005 / Bone substitutes: an update / Injury 36(Suppl 3):S20~S27
Matassi F / 2011 / New biomaterials for bone regeneration / Clin Cases Miner Bone Metab 8(1):21~24
Misra SK / 2010 / Poly(3-hydroxybutyrate)multifunctional composite scaffolds for tissue engineering applications / Biomaterials 31(10):2806~2815
Agarwal R / 2015 / Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair / Adv Drug Deliv Rev 94:53~62
Giannoudis PV / 2005 / Bone substitutes: an update / Injury 36(Suppl 3):S20~S27
Matassi F / 2011 / New biomaterials for bone regeneration / Clin Cases Miner Bone Metab 8(1):21~24
Misra SK / 2010 / Poly(3-hydroxybutyrate)multifunctional composite scaffolds for tissue engineering applications / Biomaterials 31(10):2806~2815
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