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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.3
- 수록면
- 30 - 37 (8page)
- DOI
- 10.1186/2055-7124-18-18
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초록· 키워드
오류제보하기
Background: For the effective bone regeneration with appropriate pathological/physiological properties, a variety of bone fillers have been adapted as a therapeutic treatment. However, the development of ideal bone fillers is still remained as a big challenge in clinical practice. The main aims of this study are i) fabrication of a highly porous PCL beads; and ii) the estimation of the potential use of the porous PCL beads as a bone filler through preliminary animal study. Results: The porous PCL beads with size range of 53 ~ 600 μm (425 ~ 500 μm dominantly) are fabricated by a spray/precipitation method using a double nozzle spray and PCL solution (in tetraglycol). The PCL beads show highly porous inner pore structure and the pores are interconnected with outer surface pores. For the preliminary animal study, we recognize that the porous PCL bead can induce the new bone formation from the outer surface of bone defect toward the bone marrow cavity through the bead matrix. Conclusions: From the preliminary results, we can suggest that the highly porous PCL beads may be a promising candidate as a bone filler (scaffolding matrix) for the effective bone regeneration.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Yang F. / 2013 / Bone regeneration using cell-mediated responsive degradable PEG-based scaffolds incorporating with rhBMP-2 / Biomaterials 34:1514~1528
Damien C. / 1991 / Bone graft and bone graft substitutes : a review of current technology and applications / J Appl Biomat 2:187~208
Gazdag AR. / 1995 / Alternatives to autogenous bone graft : efficacy and indications / J AM Acad Orthop Sur 3:1~8
Samit Kumar Nandi / 2008 / Efficacy of nano-hydroxyapatite prepared by an aqueous solution combustion technique in healing bone defects of goat / Journal of Veterinary Science 9(2):183~191
Hench LL. / 1991 / Bioceramics : From Concept to Clinic / J Am Ceram Soc 74:1487~1510
Damien C. / 1991 / Bone graft and bone graft substitutes : a review of current technology and applications / J Appl Biomat 2:187~208
Gazdag AR. / 1995 / Alternatives to autogenous bone graft : efficacy and indications / J AM Acad Orthop Sur 3:1~8
Samit Kumar Nandi / 2008 / Efficacy of nano-hydroxyapatite prepared by an aqueous solution combustion technique in healing bone defects of goat / Journal of Veterinary Science 9(2):183~191
Hench LL. / 1991 / Bioceramics : From Concept to Clinic / J Am Ceram Soc 74:1487~1510
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