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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 128 - 137 (10page)
- DOI
- https://doi.org/10.3350/cmh.2016.0071
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초록· 키워드
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Background/Aims: Metronomic chemotherapy (MET) is frequently administered in comparatively low doses as a continuous chemotherapeutic agent. The aim of this study was to evaluate the feasibility and overall survival (OS) of MET compared to sorafenib for advanced hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT).
Methods: A total of 54 patients with advanced HCC and PVTT who had undergone MET were analyzed between 2005 and 2013. A total of 53 patients who had undergone sorafenib therapy were analyzed as the control group. The primary endpoint of this study was OS.
Results: The median number of MET cycles was two (1-15). The OS values for the MET group and sorafenib group were 158 days (132-184) and 117 days (92-142), respectively (P=0.029). The Cox proportional-hazard model showed that a higher risk of death was correlated with higher serum alpha fetoprotein level (≥400 mg/dL, hazard ratio [HR]=1.680, P=0.014) and Child-Pugh class B (HR=1.856, P=0.008).
Conclusions: MET was associated with more favorable outcomes in terms of overall survival than was sorafenib in patients with advanced HCC with PVTT, especially in patients with poor liver function. Therefore, MET can be considered as a treatment option in patients with advanced HCC with PVTT and poor liver function.
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참고문헌 (26)
참고문헌 신청
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108
Cheng AL / 2009 / Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, doubleblind, placebo-controlled trial / Lancet Oncol 10:25~34
Llovet JM / 1999 / Prognosis of hepatocellular carcinoma: the BCLC staging classification / Semin Liver Dis 19:329~338
Llovet JM / 2003 / Hepatocellular carcinoma / Lancet 362:1907~1917
Llovet JM / 2008 / Sorafenib in advanced hepatocellular carcinoma / N Engl J Med 359:378~390
Cheng AL / 2009 / Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, doubleblind, placebo-controlled trial / Lancet Oncol 10:25~34
Llovet JM / 1999 / Prognosis of hepatocellular carcinoma: the BCLC staging classification / Semin Liver Dis 19:329~338
Llovet JM / 2003 / Hepatocellular carcinoma / Lancet 362:1907~1917
Llovet JM / 2008 / Sorafenib in advanced hepatocellular carcinoma / N Engl J Med 359:378~390
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