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논문 기본 정보

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학술저널
저자정보
Ahn Young Eun (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Suh Sang Jun (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Yim Hyung Joon (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Seo Yeon Seok (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Yoon Eileen L. (Department of Internal Medicine Inje University College of Medicine Seoul Korea) Kim Tae Hyung (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Lee Young Sun (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Yim Sun Young (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Kim Hae Rim (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Kang Seong Hee (Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Korea) Jung Young Kul (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Kim Ji Hoon (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Yeon Jong Eun (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Um Soon Ho (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Byun Kwan Soo (Department of Internal Medicine Korea University College of Medicine Seoul Korea)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제15권 제2호
발행연도
2021.1
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284 - 294 (11page)

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Background/Aims: Sorafenib is the first approved systemic treatment for advanced hepatocellular carcinoma (HCC). However, its clinical utility is limited, especially in Asian countries. Several reports have suggested the survival benefits of hepatic arterial infusion chemotherapy (HAIC) for advanced HCC with main portal vein tumor thrombosis (PVTT). This study aimed to compare the efficacy of sorafenib-based therapy with that of HAIC-based therapy for advanced HCC with main PVTT. Methods: Advanced HCC patients with main PVTT treated with sorafenib or HAIC between 2008 and 2016 at Korea University Medical Center were included. We evaluated overall survival (OS), time-to-progression (TTP), and the disease control rate (DCR). Results: Seventy-three patients were treated with sorafenib (n=35) or HAIC (n=38). Baseline characteristics were not significantly different between groups, except the presence of solid organ metastasis (46% vs 5.3%, p<0.001). The median OS time was not significantly different between the groups (6.4 months vs 10.0 months, p=0.139). TTP was longer in the HAIC group than in the sorafenib group (2.1 months vs 6.2 months, p=0.006). The DCR was also better in the HAIC group than in the sorafenib group (37% vs 76%, p=0.001). Subgroup analysis, which excluded patients with extrahepatic solid organ metastasis, showed the same trends for the median OS time (8.8 months vs 11.1 months, p=0.097), TTP (1.9 months vs 6.0 months, p<0.001), and DCR (53% vs 81%, p=0.030). Conclusions: HAIC-based therapy may be an alternative to sorafenib for advanced HCC with main PVTT by providing longer TTP and a better DCR.
#Carcinoma #hepatocellular #Portal vein thrombosis #Sorafenib #Hepatic artery #Chemotherapy

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참고문헌 (33)

참고문헌 신청
European Association for the Study of the Liver / 2018 / EASL Clinical Practice Guidelines : management of hepatocellular carcinoma / J Hepatol 69:182~236 google schola Global Burden of Disease Liver Cancer Collaboration / 2017 / The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and national level : results from the global burden of disease study 2015 / JAMA Oncol 3:1683~1691 google schola Cheng AL / 2009 / Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma : a phase III randomised, double-blind, placebo-controlled trial / Lancet Oncol 10:25~34 google schola Llovet JM / 2008 / Sorafenib in advanced hepatocellular carcinoma / N Engl J Med 359:378~390 google schola Yim HJ / 2015 / Current management of hepatocellular carcinoma : an Eastern perspective / World J Gastroenterol 21:3826~3842 google schola

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