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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.8
- 수록면
- 244 - 252 (9page)
- DOI
- 10.3393/ac.2020.00710.0101
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Purpose: The survival benefit of neoadjuvant chemotherapy (NAC) prior to surgical resection in colorectal cancer with liver metastases (CRCLM) patients remains controversial. The aim of this study was to compare overall outcome of CRCLM patients who underwent NAC followed by surgical resection versus surgical treatment first.Methods: We retrospectively analyzed 429 patients with stage IV colorectal cancer with synchronous liver metastases who underwent simultaneous liver resection between January 2008 and December 2016. Using propensity score matching, overall outcome between 60 patients who underwent NAC before surgical treatment and 60 patients who underwent surgical treatment first was compared.Results: Before propensity score matching, metastatic cancer tended to involve a larger number of liver segments and the primary tumor size was bigger in the NAC group than in the primary resection group, so that a larger percentage of patients in the NAC group underwent major hepatectomy (P<0.001). After propensity score matching, demographic features and pathologic outcomes showed no significant differences between the 2 groups. In addition, there was no significant difference in short-term recovery outcomes such as postoperative morbidity (P=0.603) and oncologic outcome, including 3-year overall survival rate (P=0.285) and disease-free survival rate (P=0.730), between the 2 groups.Conclusion: NAC prior to surgical treatment in CRCLM is considered a safe treatment that does not increase postoperative morbidity, and its impact on oncologic outcome was not inferior.
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참고문헌 (18)
참고문헌 신청
Bray F / 2018 / Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68:394~424
Manfredi S / 2006 / Epidemiology and management of liver metastases from colorectal cancer / Ann Surg 244:254~259
Nordlinger B / 1996 / Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Française de Chirurgie / Cancer 77:1254~1262
Nasti G / 2010 / Pre-operative chemotherapy for colorectal cancer liver metastases: an update of recent clinical trials / Cancer Chemother Pharmacol 66:209~218
Bismuth H / 1996 / Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant chemotherapy / Ann Surg 224:509~520
Manfredi S / 2006 / Epidemiology and management of liver metastases from colorectal cancer / Ann Surg 244:254~259
Nordlinger B / 1996 / Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Française de Chirurgie / Cancer 77:1254~1262
Nasti G / 2010 / Pre-operative chemotherapy for colorectal cancer liver metastases: an update of recent clinical trials / Cancer Chemother Pharmacol 66:209~218
Bismuth H / 1996 / Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant chemotherapy / Ann Surg 224:509~520
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