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논문 기본 정보

자료유형
학술저널
저자정보
김수현 (농촌진흥청 국립농업과학원) 조유영 (농촌진흥청 국립농업과학원) 권해용 (농촌진흥청 국립농업과학원) 이지혜 (국립농업과학원 농업생물부)
저널정보
한국잠사학회 International Journal of Industrial Entomology International Journal of Industrial Entomology 제43권 제2호
발행연도
2021.12
수록면
45 - 51 (7page)
DOI
https://doi.org/10.7852/ijie.2021.43.2.45

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High blood cholesterol levels and oxidized cholesterol are risk factors for cardiovascular disease, which displays high annual incidence. Although studies on sericulture products, including pupae, silk protein, and blood lymph, as hypocholesterolemic substances have been reported, insufficient research in this field has been focused on silkworm larvae. Six larval extracts (Low temperature distilled water, LW; hot temperature distilled water, HW; and 30- 100% ethanol, E30-E100) were prepared, and their effects on cholesterol metabolism were examined. LW most potently reduced the risk of cholesterol-related disorders. Polyphenols were highly represented in LW, corresponding with its increased antioxidant potency. The cholesterol biosynthesis enzyme, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) was strongly inhibited by LW. Hepatocytes over-expressed LDL receptor (LDLR) after LW stimulation, promoting cholesterol elimination from plasma. LW also increased ATP binding cassette transporter 1 (ABCA1) gene expression, upregulating HDL biogenesis. In conclusion, LW exhibited strong antioxidant activity, suppressed cholesterol biosynthesis, improved LDL uptake from plasma, and upregulated HDL biosynthesis. In aggregate, these activities could reduce blood cholesterol levels and prevent cardiovascular disease.

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