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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.8
- 수록면
- 696 - 702 (7page)
- DOI
- 10.9799/ksfan.2017.30.4.696
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초록· 키워드
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Metabolic syndrome, including obesity, glucose intolerance and elevated blood pressure, is related to type 2 diabetes and cardiovascular disease. Previous studies have reported the anti-oxidative, anti-inflammatory and anti-diabetic effects of purple corn extract. We investigated the efficacy of purple corn extract (PC) against high-fat diet (HFD)-induced obesity and glucose intolerance, and examined the underlying mechanisms by analyzing expression of proteins and genes involved in glucose regulation and macrophage infiltration. C57BL/6 mice were fed with normal chow diet (ND), or HFD treated with distilled water (DW, control) or PC, for 10 weeks. Although body weights were similar in the HFD-fed groups, we observed a decrease in the liver and epididymal adipose tissue (EAT) weights, and enhanced glucose tolerance test (GTT) results in the PC group, as compared with DW group. Liver showed increased Akt phosphorylation in the PC-treated mice; however, no changes were observed in the EAT, for all groups. In PC-treated mice, decreased macrophage infiltration was seen in the EAT, with a reduced expression of macrophage marker genes. Finally, proin?ammatory cytokine gene expressions were decreased by PC in the EAT, and a modest trend for downregulation was observed in the liver. Hence, we conclude that PC may decrease glucose intolerance by increasing the phosphorylation of Akt and reducing the macrophage infiltration into the EAT.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Bennett WL / 2011 / Comparative effectiveness and safety of medications for type 2 diabetes : an update including new drugs and 2-drug combinations / Ann Intern Med 154:602~613
Bornfeldt KE / 2011 / Insulin resistance, hyperglycemia, and atherosclerosis / Cell Metab 14:575~585
Daud MA / 2008 / How good is red cabbage extract for lower-ing high blood glucose and alleviating pain? A preliminary evaluation of Brassica oleracea L. var. capitata f. rubra / WJPPS 4:1642~1651
Eledrisi MS / 2006 / Overview of the diagnosis and management of diabetic ketoacidosis / Afr J Med Med Sci 331:243~251
Giusti MM / 2001 / Current Protocols in Food Analytical Chemistry. Unit F1.2 / John Wiley and Sons, Inc :1~13
Bornfeldt KE / 2011 / Insulin resistance, hyperglycemia, and atherosclerosis / Cell Metab 14:575~585
Daud MA / 2008 / How good is red cabbage extract for lower-ing high blood glucose and alleviating pain? A preliminary evaluation of Brassica oleracea L. var. capitata f. rubra / WJPPS 4:1642~1651
Eledrisi MS / 2006 / Overview of the diagnosis and management of diabetic ketoacidosis / Afr J Med Med Sci 331:243~251
Giusti MM / 2001 / Current Protocols in Food Analytical Chemistry. Unit F1.2 / John Wiley and Sons, Inc :1~13
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