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Brown alga (Ishige okamurae; IO) dietary supplements have been reported to possess anti-diabetic properties. However, the effects of IO supplements have not been evaluated on glucose metabolism in the pancreas and skeletal muscle. C57BL/6 N male mice (age, 7 weeks) were arranged in five groups: a chow diet with 0.9% saline (NFD/saline group), high-fat diet (HFD) with 0.9% saline (HFD/saline group). high-fat diet with 25 mg/kg IO extract (HFD/25/IOE). high-fat diet with 50 mg/kg IO extract (HFD/50/IOE), and high-fat diet with 75 mg/kg IO extract (HFD/ 75/IOE). After 4 weeks, the plasma, pancreas, and skeletal muscle samples were collected for biochemical analyses. IOE significantly ameliorated glucose tolerance impairment and fasting and 2 h blood glucose level in HFD mice. IOE also stimulated the protein expressions of the glucose transporters (GLUTs) including GLUT2 and GLUT4 and those of their related transcription factors in the pancreases and skeletal muscles of HFD mice, enhanced glucose metabolism, and regulated blood glucose level. Our results suggest Ishige okamurae extract may reduce blood glucose levels by improving glucose metabolism in the pancreas and skeletal muscle in HFD-induced diabetes.
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참고문헌 (46)
참고문헌 신청
Bell GI / 2001 / Diabetes mellitus and genetically programmed defects in β-cell function / Nature 414:788
Bonny C / 1997 / The loss of GLUT2expression in the pancreatic β-cells of diabetic db/db mice is associated with an impaired DNA-binding activity of islet-specific trans-acting factors / Mol Cell Endocrinol 135:59~65
Bringhenti I / 2013 / Maternal obesity during the preconception and early life periods alters pancreatic development in early and adult life in male mouse offspring / PLOS ONE 8:e55711
Butler AE / 2003 / β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes / Diabetes 52:102~110
Carey DG / 1996 / Abdominal fat and insulin resistance in normal and overweight women : direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM / Diabetes 45:633~638
Bonny C / 1997 / The loss of GLUT2expression in the pancreatic β-cells of diabetic db/db mice is associated with an impaired DNA-binding activity of islet-specific trans-acting factors / Mol Cell Endocrinol 135:59~65
Bringhenti I / 2013 / Maternal obesity during the preconception and early life periods alters pancreatic development in early and adult life in male mouse offspring / PLOS ONE 8:e55711
Butler AE / 2003 / β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes / Diabetes 52:102~110
Carey DG / 1996 / Abdominal fat and insulin resistance in normal and overweight women : direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM / Diabetes 45:633~638
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