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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 353 - 366 (14page)
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Objective: This study aimed to use a mouse model to evaluate the effects of Gwaruhaengryeon-hwan (GHH) on chronic obstructive pulmonary disease (COPD) and particulate matter induced lung injury.
Materials and Methods: The study was carried out in two ways (in vitro, in vivo). In vitro RAW 264.7 cells (mouse macrophage) were used and analyzed by flow cytometry, ELISA. In vivo lipopolysaccharide (LPS) and cigarette smoke solution (CSS), or coal, fly ash, diesel exhaust particle (CFD) challenged mice were used and its BALF was analyzed by ELISA, lung tissue by real-time PCR.
Results: In vitro, GHH maintained an 80-100% rate of viability. So cytotoxicity was not shown. In the ELISA analysis with RAW 264.7 cells, GHH significantly decreased NO over 30 μg/ml. In the ELISA analysis, GHH significantly decreased TNF-α, IL-6 over 300 μg/ml. In the COPD model, the GHH 200 mg/kg dosage group, the application of GHH significantly decreased the increasing of neutrophils, TNF-α, IL-17A, MIP2, CXCL-1 in BALF, TNF-α, IL-1β mRNA expression in lung tissue and histological lung injury. In the CFD induced lung injury model, the GHH 200 mg/kg dosage group, the application of GHH significantly decreased the increase of neutrophils, TNF-α, IL-17A, MIP2, CXCL-1 in BALF, MUC5AC, TGF-β mRNA expression in lung tissue and histological lung injury.
Conclusion: This study suggests the usability of GHH for COPD patients by controlling lung tissue injury.
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참고문헌 (35)
참고문헌 신청
Global Initiative for Chronic Obstructive Lung Disease / Global Strategy for Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease 2017 Report
유철규 / 2009 / 만성폐쇄성폐질환의 병인과 병태생리 / 대한내과학회지 77(4):383~400
Pelkonen M / 2008 / Smoking: relationship to chronic bronchitis, chronic obstructive pulmonary disease and mortality / CurrOpinPulm Med 14(2):105~109
Rodriguez-Roisin R / 2000 / Toward a consensus definition for COPD exacerbations / Chest 117:398S~401S
Sint T / 2008 / Ambient air pollution particles and the acute exacerbation of chronic obstructive pulmonary disease / InhalToxicol 20(1):25~29
유철규 / 2009 / 만성폐쇄성폐질환의 병인과 병태생리 / 대한내과학회지 77(4):383~400
Pelkonen M / 2008 / Smoking: relationship to chronic bronchitis, chronic obstructive pulmonary disease and mortality / CurrOpinPulm Med 14(2):105~109
Rodriguez-Roisin R / 2000 / Toward a consensus definition for COPD exacerbations / Chest 117:398S~401S
Sint T / 2008 / Ambient air pollution particles and the acute exacerbation of chronic obstructive pulmonary disease / InhalToxicol 20(1):25~29
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