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Objectives: This study is aimed to evaluate the protective effects of GGX on lung injury of Chronic Obstructive Lung Disease (COPD) mice model.
Materials and Methods: C57BL/6 mice were challenged with lipopolysaccharide (LPS) and cigarette smoke extract (CSE) and then treated with vehicle only (Control group), dexamethasone 3 ㎎/㎏ (Dexa group), gam-gil-tang 200 ㎎/㎏ (GGT group), GGX 100, 200, and 400 ㎎/㎏ (GGX group). After sacrifice, its bronchoalveolar lavage fluid (BALF) or lung tissue was analyzed with cytospin, Enzyme-Linked Immunosorbent Assay (ELISA), real-time polymerase chain reaction (PCR) and hematoxylin & eosin (H&E), and Masson’s trichrome staining.
Results: In the COPD model, GGX significantly inhibited the increase of neutrophils, TNF-α, IL-17A, CXCL-1, MIP2 in BALF and TNF-α, IL-1β, IL-10 mRNA expression in lung tissue. It also decreased the severity of histological lung injury.
Conclusion: This study suggests the usability of GGX for COPD patients by controlling lung tissue injury.
Materials and Methods: C57BL/6 mice were challenged with lipopolysaccharide (LPS) and cigarette smoke extract (CSE) and then treated with vehicle only (Control group), dexamethasone 3 ㎎/㎏ (Dexa group), gam-gil-tang 200 ㎎/㎏ (GGT group), GGX 100, 200, and 400 ㎎/㎏ (GGX group). After sacrifice, its bronchoalveolar lavage fluid (BALF) or lung tissue was analyzed with cytospin, Enzyme-Linked Immunosorbent Assay (ELISA), real-time polymerase chain reaction (PCR) and hematoxylin & eosin (H&E), and Masson’s trichrome staining.
Results: In the COPD model, GGX significantly inhibited the increase of neutrophils, TNF-α, IL-17A, CXCL-1, MIP2 in BALF and TNF-α, IL-1β, IL-10 mRNA expression in lung tissue. It also decreased the severity of histological lung injury.
Conclusion: This study suggests the usability of GGX for COPD patients by controlling lung tissue injury.
목차
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (45)
참고문헌 신청
박용범 / 2018 / Revised (2018) COPD Clinical Practice Guideline of the Korean Academy of Tuberculosis and Respiratory Disease: A Summary / Tuberculosis and Respiratory Diseases 81(4):261~273
Barnes PJ / 2003 / Chronic obstructive pulmonary disease: molecular and cellular mechanisms / Eur Respir J 22(4):672~688
김인애 / 2018 / 만성폐쇄성폐질환의 약물요법 / 대한의사협회지 61(9):545~551
Anthonisen NR / 1994 / Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1: the Lung Health Study / JAMA 272:1497~1505
Singh S / 2009 / Long-term use of inhaled corticosteroids and the risk of pneumonia in chronic obstructive pulmonary disease: a meta-analysis / Arch Intern Med 169:219~229
Barnes PJ / 2003 / Chronic obstructive pulmonary disease: molecular and cellular mechanisms / Eur Respir J 22(4):672~688
김인애 / 2018 / 만성폐쇄성폐질환의 약물요법 / 대한의사협회지 61(9):545~551
Anthonisen NR / 1994 / Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1: the Lung Health Study / JAMA 272:1497~1505
Singh S / 2009 / Long-term use of inhaled corticosteroids and the risk of pneumonia in chronic obstructive pulmonary disease: a meta-analysis / Arch Intern Med 169:219~229
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