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학술저널
저자정보
Mansoor Tabeen (Department of Microbiology Government Medical College Srinagar India.) Koul Ajaz Nabi (Medicine and Infectious Disease SKIMS Soura India.) Bhat Mushtaq Ahmad (Department of Neonatology SKIMS Soura India.) Abdullah Nazima (Department of Microbiology SKIMS Soura India.) Bhattacharya Sudip (Independent Public Health Researcher Dehradun India.) Saleem Sheikh Mohd (Independent Public Health Researcher J&K India.) Fomda Bashir Ahmad (Department of Microbiology SKIMS Soura India.)
저널정보
대한감염학회 Infection and Chemotherapy Infection and Chemotherapy 제53권 제4호
발행연도
2021.12
수록면
814 - 816 (3page)

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Title Before: Rickettsial Infections among the Undifferentiated Febrile Patients Attending a Tertiary Care Teaching Hospital of Northern India: A Longitudinal Study. After: Aetiological Agents Causing Undifferentiated fever in patients attending a Tertiary Care Teaching Hospital of Northern India: A Longitudinal Study. Author Before: Tabeen Mansoor1, Bashir Ahmad Fomda2, Ajaz Nabi Koul3, Mushtaq Ahmad Bhat4, Nazima Abdullah2, Sudip Bhattacharya5, and Sheikh Mohd Saleem6 After: Tabeen Mansoor1, Bashir Ahmad Fomda1, Ajaz Nabi Koul2, Mushtaq Ahmad Bhat3, and Nazima Abdullah1 Affiliation Before: 1Department of Microbiology, Government Medical College, Srinagar, India. 2Department of Microbiology, SKIMS Soura, India. 3Medicine and Infectious Disease, SKIMS Soura, India. 4Department of Neonatology, SKIMS Soura, India. 5Independent Public Health Researcher, Dehradun, India. 6Independent Public Health Researcher, J&K, India. After: 1Department of Microbiology, Sher-i-Kashmir Institute Of Medical Sciences, Srinagar, India. 2Department of Medicine and Infectious Diseases, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India. 3Department of Neonatology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India. Corresponding Author Before: Corresponding Author: Tabeen Mansoor, MD. Department of Microbiology, Government Medical College, Srinagar, J&K, India. Tel: 7006806993, Email: researcheracademics007@gmail.com After: Corresponding Author: Bashir Ahmad Fomda, MD. Department of Microbiology, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar-190011, India. Tel: +919419001701, Email: bashirfomda@gmail.com Abstract Abstracts should be corrected as the following: Background: Acute undifferentiated febrile illness (AUFI) is one of the most daunting challenges a physician faces in such settings. Among AUFI, rickettsial infections are most common and related infections (such as anaplasmosis, ehrlichiosis, and Q fever) which are caused by an unusual type of bacteria that can live only inside the cells of another organism. The present study was therefore planned with an objective to find the aetiological agents responsible for causing undifferentiated fever in our study. Materials and Methods: Patients presenting with febrile illness and admitted or attending out-patient department of Sher-i-Kashmir Institute of Medical Sciences, Srinagar were approached and recruited in the study. Weil Felix Assay, enzyme-linked immunosorbent assay and indirect immunofluorescence assay were done to detect the anti-rickettsial antibodies. Serological evidence of a fourfold increase in IgG-specific antibody titer reactive with group specific rickettsial antigen by indirect immunofluorescence antibody assays between paired serum specimens was considered a confirmatory diagnosis for the rickettsial disease. Serological tests for etiological agents like Salmonella, Brucella, Epstein-Barr virus infection, Dengue, Leptospirosis were also carried. Results: Most of the patients were males 61.6% (212) and most 46.2% (159) were in the age group of 20 -39 years. Most of the patients, 80.8% (278) belonged to rural areas, and 48% (165) belonged to the upper middle (II) class of the socio-economic class according to modified Kuppuswamy scale. Of the studied participants, a majority, 47.0% (162), were determined undiagnosed, while 15.4% (54) studied participants were diagnosed to have a rickettsial disease. In patients positive for typhus group, 67.8% (19) were IgM positive, 28.5% (8) were IgG positive, and only 3% (1) were positive for IgM and IgG. In patients positive for Scrub Typhus Group, 32.7% (19) were positive for IgM, and 62.0% (36) were positive for IgG, and only 5.0% (3) were positive for both IgM and IgG. In patients positive for spotted fever group, 36.1% (13) were positive for IgM, and 58.5% (21) were positive for IgG, and only 5.5% (2) were positive for both IgM and IgG. The prevalence of rickettsial disease was found to be 15.4% (53), Leptospirosis -6.3% (22), Salmonellosis 13.3% (46)and Brucellosis 10.4(36)%. Conclusion: Rickettsial diseases, typhoid and brucellosis, were the most prevalent diseased diagnosed among patients reporting to hospitals with undifferentiated febrile illness. Clinicians must consider rickettsial diseases as one of the differential diagnosis while treating patients with fever. Keywords: Undifferentiated fever, Rickettsial Infections, Leptospirosis, Scrub Typhus, Epstein-Barr virus infection, Brucellosis, Salmonellosis INTRODUCTION Before: to estimate the prevalence of rickettsial infection among patients of AUFI who reported After: to find the aetiological agents responsible for causing undifferentiated fever in our study. Before: to determine any association of socio- demographic characteristics like gender, age, place of residence and socio-economic status with the rickettsial disease among the studied sample. After: Delete MATERIAL AND METHODS Before: spotted fever group rickettsioses After: group specific rickettsial Before: Chikungunya After: Omitted throughout the paper. Before: poor hygiene practices, greater exposure to contaminated water of people living in villages. After: Delete Funding FUNDING: The authors acknowledge the funding provided by DHR, ICMR, Govt. of India without which the research work would never have been completed. A part of the research was also funded by the research grant provided by the Sher-i-Kashmir Institute of Medical Sciences.

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