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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 123 - 129 (7page)
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초록· 키워드
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Background: Varicella-zoster virus (VZV) is one of the most common etiologies of aseptic meningitis. The severest manifestation of VZV meningitis is occasionally confused with tuberculous meningitis (TBM). Thus, we investigated the clinical manifestations of VZV meningitis as compared with those of TBM.
Materials and Methods: All adult patients who were diagnosed with VZV meningitis or TBM were enrolled at a tertiary hospital in Seoul, South Korea, during an 8-year period. The clinical characteristics and cerebrospinal fluid (CSF) profile of patients were analyzed.
Results: Seventy-nine patients with VZV meningitis and 24 patients with TBM were enrolled in this study. Of the 79 patients with VZV meningitis, 63 (80%) did not received empirical anti-tuberculous therapy (Group 1) and the remaining 16 (20%) received empirical anti-tuberculous therapy (Group 2), compared with 24 patients with TBM (Group 3). Altered mental status, intensive care unit (ICU) admission, neurologic sequelae, CSF protein levels, and CSF adenosine deaminase levels revealed a trend of being higher in Group 3 than Group 2, which was higher than Group 1. However, the CSF/serum glucose ratio was significantly lower in Group 3 than in Group 1 or Group 2.
Conclusion: About one fifth of VZV meningitis cases presented as severe manifestations, mimicking TBM. The CSF/serum glucose ratio might be useful to differentiate VZV meningitis from TBM until definite diagnostic tests are available. Physicians should keep in mind that a differential diagnosis between severe VZV meningitis and TBM is needed.
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참고문헌 (22)
참고문헌 신청
Grahn A / 2015 / Varicella-zoster virus infections of the central nervous system – prognosis, diagnostics and treatment / J Infect 71:281~293
이정은 / 2016 / A Case of Transverse Myelitis Caused by Varicella Zoster Virus in an Immunocompetent Older Patient / Infection and Chemotherapy 48(4):334~337
Ihekwaba UK / 2008 / Clinical features of viral meningitis in adults: significant differences in cerebrospinal fluid findings among herpes simplex virus, varicella zoster virus, and enterovirus infections / Clin Infect Dis 47:783~789
Glaser CA / 2003 / California Encephalitis Project, 1998-2000. In search of encephalitis etiologies: diagnostic challenges in the California Encephalitis Project, 1998-2000 / Clin Infect Dis 36:731~742
Persson A / 2009 / Varicella-zoster virus CNS disease--viral load, clinical manifestations and sequels / J Clin Virol 46:249~253
이정은 / 2016 / A Case of Transverse Myelitis Caused by Varicella Zoster Virus in an Immunocompetent Older Patient / Infection and Chemotherapy 48(4):334~337
Ihekwaba UK / 2008 / Clinical features of viral meningitis in adults: significant differences in cerebrospinal fluid findings among herpes simplex virus, varicella zoster virus, and enterovirus infections / Clin Infect Dis 47:783~789
Glaser CA / 2003 / California Encephalitis Project, 1998-2000. In search of encephalitis etiologies: diagnostic challenges in the California Encephalitis Project, 1998-2000 / Clin Infect Dis 36:731~742
Persson A / 2009 / Varicella-zoster virus CNS disease--viral load, clinical manifestations and sequels / J Clin Virol 46:249~253
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