지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 103 - 111 (9page)
이용수
초록· 키워드
오류제보하기
Varicella zoster virus (VZV) causes two distinct diseases, varicella (chickenpox) during primary infection, and herpes zoster (shingles) resulting from reactivation. The purpose of this review is to summarize the present understanding of VZV and the associated immune response, as well as to discuss available vaccines. VZV infection induces both innate and adaptive immune responses, especially an antigen-specific adaptive immune response, which activates humoral immunity and cell-mediated immunity (CMI). Reactivation of VZV can occur when the CMI of latent VZV is reduced, leading to herpes zoster. After VZV infection, natural killer (NK) cells modulate antigen presentation and the production of IFN-γ, an important activator of macrophages. IFN-γ is produced by NK cells and CD4 Th1/CD8 cytotoxic T lymphocytes. The T cell-mediated immune response is an important factor influencing VZV reactivation and herpes zoster, with herpes zoster being associated with reduced levels of VZV-specific T cells. Since the VZV-specific T cell population gradually declines with age, herpes zoster particularly affects the elderly. There are two types of zoster vaccines: live-attenuated and recombinant subunit. However, recombinant vaccines generally have poor immunogenicity when administered alone and require an adjuvant. Therefore, effective adjuvants are needed that especially promote cell-mediated immune responses. Various adjuvants have been developed, many of which enhance T cell immunity more than antibody-based humoral immunity. The information presented in this review may serve as a reference for future VZV immunology studies.
목차
INTRODUCTION
IMMUNOLOGY OF VZV INFECTION
HERPES ZOSTER VACCINES AND IMMUNE RESPONSE
ADJUVANTS
CONCLUSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
의료기관에서의 수두 감염관리
의료관련감염관리
2021 .12
-
수두-대상포진 바이러스의 재활성에 의해 유발되는 다양한 임상질환
Journal of Yeungnam Medical Science
2016 .06
-
수두-대상포진 바이러스의 재활성에 의해 유발되는 다양한 임상질환
영남의대학술지
2016 .01
-
Implementation of Hospital Policy for Healthcare Workers and Patients Exposed to Varicella-Zoster Virus
Journal of Korean Medical Science
2018 .01
-
Herpes Zoster DNA Vaccines with IL-7 and IL-33 Molecular Adjuvants Elicit Protective T Cell Immunity
Immune Network
2018 .10
-
Herpes Zoster with Aseptic Meningitis in Immunocompetent Children: A Case Series
대한소아신경학회지
2017 .01
-
Diagnostic Usefulness of Varicella Zoster Virus-Specific Immunoglobulin (Ig) A and IgG in Patients With Herpes Zoster
Journal of Korean Medical Science
2023 .01
-
Range of Varicella Zoster Co-Infections with COVID-19, Singapore
Infection and Chemotherapy
2021 .01
-
Optimal Timing of Zoster Vaccination After Shingles: A Prospective Study of the Immunogenicity and Safety of Live Zoster Vaccine
Infection and Chemotherapy
2018 .01
-
A Study of the Changes of T Helper 17 Cells and Regulatory T Cells in Herpes Zoster
Annals of Dermatology
2017 .01
-
재발성 이성대상포진과 동반된 성대마비 없는 대상포진 인후두염 1예
대한후두음성언어의학회지
2019 .01
-
수두-대상포진 바이러스에 노출된 소아 환자의예방 조치
Pediatric Infection and Vaccine
2016 .01
-
Clinical characteristics and outcomes of varicella zoster virus infection in children with hematologic malignancies in the acyclovir era
Blood Research
2016 .01
-
A Case Report of Herpes Zoster Ophthalmicus and Meningitis After COVID-19 Vaccination
Journal of Korean Medical Science
2022 .05
-
Genetic Change of Varicella-Zoster Virus Propagated in Cell Culture in Non-Natural Conditions
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2021 .12
-
A Case of Transverse Myelitis Caused by Varicella Zoster Virus in an Immunocompetent Older Patient
Infection and Chemotherapy
2016 .12
-
Epidemiological Study on the Incidence of Herpes Zoster in Nearby Cheonan
The Korean Journal of Pain
2015 .01
-
Herpes Zoster and Postherpetic Neuralgia: Practical Consideration for Prevention and Treatment
The Korean Journal of Pain
2015 .01
-
Disseminated herpes zoster with vagus nerve involvement in a kidney transplant recipient: a case report
고신대학교 의과대학 학술지
2024 .06
-
A Case Report of Varicella Zoster Meningitis as Co-Infection With Breakthrough COVID-19 in an Immunocompetent Patient
Journal of Korean Medical Science
2022 .02
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2021-475-002143181