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학술저널
저자정보
김상훈 (전남대학교 의과대학 신경과학교실) 최성민 (전남대학교) 김병채 (전남대학교병원) 최강호 (전남대학교 의과대학 신경과학교실) 남태승 (전남대학교) 김준태 (전남대학교) 이승한 (전남대학교) 박만석 (전남대학교) 김성진 (전남대학교)
저널정보
대한피부과학회 Annals of Dermatology Annals of Dermatology 제29권 제3호
발행연도
2017.6
수록면
283 - 287 (5page)

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Background: Herpes zoster (HZ) is caused by reactivation of latent varicella-zoster virus (VZV) infection. HZ-associated aseptic meningitis, a rare complication of HZ, can require hospitalization and a long treatment period. Objective: A retrospective study was performed to identify potential factors associated with HZ-associated aseptic meningitis development. Methods: We included all outpatients and patients admitted in the neurology and dermatology departments of a single tertiary center, who were diagnosed with HZ for two years. Among 818 patients, 578 patients were eligible for analysis. Results: The demographics and potential risk factors were compared between the uncomplicated HZ group (n=554) and aseptic meningitis group (n=24). Among the potential factors, the dermatological distribution of skin rash and gender showed statistically significantly different between the two groups. Patients with craniocervical distribution of HZ accounted for 87.5% (n=21) of the aseptic meningitis group and 54.3% (n=301) of the uncomplicated HZ group (p=0.043). The aseptic meningitis group had more men (66.7%, n=16) than the uncomplicated HZ group (42.8%, n=237, p=0.033). Patients with craniocervical distribution had an odds ratio (OR) of 5.884 (p=0.001) for developing aseptic meningitis when compared with the other dermatome involvements. Additional logistic regression analysis resulted in a fading between gender difference (p=0.050) and craniocervical involvement having an OR of 5.667 for aseptic meningitis (p=0.006). Conclusion: In HZ patients, skin rash with craniocervical distribution and male gender were associated with a higher risk of aseptic meningitis.

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