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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 117 - 122 (6page)
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초록· 키워드
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Background: In March 2013, human infection with avian influenza A (H7N9) virus emerged in China, causing serious public health concerns and raising the possibility of avian-source pandemic influenza. Thus, the development of an effective vaccine for preventing and rapidly controlling avian influenza A (H7N9) virus is needed. In this study, we evaluated the immunogenicity of a synthetic DNA vaccine against H7 HA antigens in mice.
Materials and Methods: The synthetic consensus H7 HA DNA vaccine (25 or 50 μg) was administered to BALB/c mice at 0, 14, and 28 days by intramuscular injection followed by electroporation. Humoral and cellular immune responses were analyzed in a hemagglutination inhibition test and interferon-gamma enzyme-linked immunospot (ELISpot) assay, respectively.
Results: H7 HA-vaccinated mice showed 100% seroprotection and seroconversion rate against H7N9 reassortant influenza virus after both second and third immunizations. The geometric mean titer by the hemagglutination inhibition test increased with an increasing number of immunizations. However, there was no significant difference in geometric titer between the two groups injected with 25 and 50 μg of H7 HA DNA vaccine after two (79.98 vs. 107.65, P = 0.39) and three (159.96 vs. 215.28, P = 0.18) doses. In addition, the ELISpot assay revealed that administration of H7 HA DNA vaccine induced potent interferon-gamma production from mouse splenocytes.
Conclusion: This study demonstrated the humoral and cellular immunogenicity of synthetic consensus H7 HA DNA vaccine in mice. This work demonstrates the potential of the H7 HA DNA vaccine as an efficient tool for the rapid control of emerging influenza A (H7N9) virus.
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참고문헌 (18)
참고문헌 신청
Hilleman MR / 2002 / Realities and enigmas of human viral influenza: pathogenesis, epidemiology and control / Vaccine 20:3068~3087
Simonsen L / 1998 / Pandemic versus epidemic influenza mortality: a pattern of changing age distribution / J Infect Dis 178:53~60
Gao R / 2013 / Human infection with a novel avian-origin influenza A (H7N9) virus / N Engl J Med 368:1888~1897
Husain M / 2014 / Avian influenza A (H7N9) virus infection in humans: epidemiology, evolution, and pathogenesis / Infect Genet Evol 28:304~312
Kageyama T / 2013 / Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013 / Euro Surveill 18:20453
Simonsen L / 1998 / Pandemic versus epidemic influenza mortality: a pattern of changing age distribution / J Infect Dis 178:53~60
Gao R / 2013 / Human infection with a novel avian-origin influenza A (H7N9) virus / N Engl J Med 368:1888~1897
Husain M / 2014 / Avian influenza A (H7N9) virus infection in humans: epidemiology, evolution, and pathogenesis / Infect Genet Evol 28:304~312
Kageyama T / 2013 / Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013 / Euro Surveill 18:20453
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