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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제6호
- 발행연도
- 2021.10
- 수록면
- 525 - 532 (8page)
- DOI
- 10.4196/kjpp.2021.25.6.525
이용수
초록· 키워드
오류제보하기
We have investigated the relative roles of α1-adrenoceptors and purinoceptors in contractions to low and high frequency stimulation of the mouse vas deferens, in terms of the time course of responses. In separate experiments, isometric contractile responses were obtained to 10 pulses at 1 Hz and 40 pulses at 10 Hz. Responses to 1 Hz stimulation consisted of a series of discrete peaks. The α1A-adrenoceptor antagonist RS100329 (10?9M?10?7M) significantly reduced the response to the first pulse, the α1D-adrenoceptor antagonist BMY7378 (10?7M?10?6M) significantly reduced the response to the first two pulses, and the non-selective α1- adrenoceptor antagonist prazosin (10?8M) reduced the response to the first 4 pulses at 1 Hz. Responses to 10 Hz stimulation consisted of an early peak response and a maintained plateau response. RS100329 significantly reduced the peak response but did not significantly affect the plateau response. Prazosin, significantly reduced both the peak and plateau responses. The α1A-adrenoceptor antagonist RS17053 in high concentrations reduced mainly the plateau response leaving a clear early peak response. The plateau response of contraction was almost abolished by the purinoceptor antagonist suramin. These results suggest that there is a relatively minor early α1D-adrenoceptor and a larger early α1A-adrenoceptor component to stimulationevoked contractions of mouse vas deferens, but the major α1-adrenoceptor component is revealed by prazosin to be α1B-adrenoceptor mediated. α1B-Adrenoceptor activation probably facilitates contractions mediated by other α1-adrenoceptors and by purinoceptors. These results suggest that combined non-selective α1-adrenoceptor blockade, particularly α1B-adrenoceptor blockade, in addition to P2X1-purinoceptor blockade is useful in reducing male fertility
목차
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참고문헌 (27)
참고문헌 신청
Young JS / 2007 / Electrical and optical study of nerve impulse-evoked ATP-induced, P2X-receptor-mediated sympathetic neurotransmission at single smooth muscle cells in mouse isolated vas deferens / Neuroscience 148:82~91
Bexis S / 2008 / Alpha1D-adrenoceptors mediate nerve and agonist-evoked contractions in mouse vas deferens : evidence obtained from knockout technology / Auton Autacoid Pharmacol 28:81~85
Docherty JR / 2013 / Prazosin has low potency at α1A-adrenoceptors and high potency at α1D-adrenoceptors in rat vas deferens / Auton Autacoid Pharmacol 33:49~57
Gorodeski GI / 2015 / Purinergic signalling in the reproductive system / Auton Neurosci 191:82~101
White CW / 2013 / Male contraception via simultaneous knockout of α1A-adrenoceptors and P2X1-purinoceptors in mice / Proc Natl Acad Sci U S A 110:20825~20830
Bexis S / 2008 / Alpha1D-adrenoceptors mediate nerve and agonist-evoked contractions in mouse vas deferens : evidence obtained from knockout technology / Auton Autacoid Pharmacol 28:81~85
Docherty JR / 2013 / Prazosin has low potency at α1A-adrenoceptors and high potency at α1D-adrenoceptors in rat vas deferens / Auton Autacoid Pharmacol 33:49~57
Gorodeski GI / 2015 / Purinergic signalling in the reproductive system / Auton Neurosci 191:82~101
White CW / 2013 / Male contraception via simultaneous knockout of α1A-adrenoceptors and P2X1-purinoceptors in mice / Proc Natl Acad Sci U S A 110:20825~20830
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