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논문 기본 정보

자료유형
학술저널
저자정보
Guojin Gong (Department of Gastrointestinal Surgery Xichang People's Hospital Xichang 615000 China) Rigetu Zhao (Department of Gastroenterology The Affiliated Hospital of Inner Mongolia University for Nationaliti) Yuhui Zhu (Department of Pharmacy The Second Hospital of Jilin University Changchun 130041 China) Jinfeng Yu (General Medicine Yantaishan Hospital Yantai 264001 China) Bin Wei (The People's Hospital of Guangxi Zhuang Autonomous Region Nanning 530021 China) Yan Xu (Chongqing University Affiliated Tumor Hospital/Chongqing Cancer Institute Chongqing 400030 China) Zhaoxun Cui (Department of Oncology Shaanxi Forest Industry Hospital Xi’an 710000 China) Guoying Liang (Department of Liver Spleen and Stomach Diseases First Affiliated Hospital of Heilongjiang Universit)
저널정보
대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제5호
발행연도
2021.9
수록면
403 - 411 (9page)
DOI
10.4196/kjpp.2021.25.5.403

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This study was designed to evaluate the gastroprotective activity of cirsilineol in hydrochloric acid (HCl)/ethanol-induced gastric ulcer model. Cirsilineol was administered at the doses of 20 and 40 mg/kg in HCl/ethanol-induced rats. The gastroprotective ability was verified by determining the ulcer score, total acidity, hemoglobin, inflammatory cytokines, lipid peroxides, and enzymatic antioxidants superoxide dismutase (SOD) and catalase (CAT) in gastric tissue and serum biochemical analysis. The results showed a favorable increase in the hemoglobin level, antioxidant enzymes (SOD and CAT), restored electrochemical balance (carbon dioxide & anion gap) while a noticeable decrease in ulcer index, total acidity, lipid peroxides, inflammatory cytokines (interleukin-1 beta [IL-1β], IL-6, and tumor necrosis factor alpha) in rats treated with the cirsilineol. The serum biochemical analysis on liver markers (alkaline phosphatases, alanine aminotransferase, and aspartate aminotransferase), kidney markers (urea, creatinine, albumin, globulin, total protein), and lipid profile (triglyceride, high-density lipoprotein, total cholesterol) were attenuated by cirsilineol treatment in rats. Histopathology showed enhanced gastric protection and preserved the integrity of gastric mucosa upon cirsilineol administration. These results ultimately suggest that cirsilineol has gastroprotective effects that prevent the development of gastric ulcer.

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