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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 186 - 194 (9page)
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The present study developed an oral hepatocyte growth factor (HGF) gene therapy strategy for gastric ulcers treatment. An attenuated Salmonella typhimurium that stably expressed high HGF (named as TPH) was constructed, and the antiulcerogenic effect of TPH was evaluated in a rat model of gastric ulcers that created by acetic acid subserosal injection. From day 5 after injection, TPH (1 × 109 cfu), vehicle (TP, 1 × 109 cfu), or sodium bicarbonate (model control) was administered orally every alternate day for three times. Then ulcer size was measured at day 21 after ulcer induction. The ulcer area in TPH-treated group was 10.56 ± 3.30 mm2, which was smaller when compared with those in the TP-treated and model control groups (43.47 ± 4.18 and 56.25 ± 6.38 mm2, respectively). A higher level of reepithelialization was found in TPH-treated group and the crawling length of gastric epithelial cells was significantly longer than in the other two groups (P < 0.05). The microvessel density in the ulcer granulation tissues of the TPH-treated rats was 39.9 vessels/mm2, which was greater than in the TP-treated and model control rats, with a significant statistical difference. These results suggest that TPH treatment significantly accelerates the healing of gastric ulcers via stimulating proliferation of gastric epithelial cells and enhancing
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참고문헌 (26)
참고문헌 신청
Tanaka T / 2014 / Expression level of sonic hedgehog correlated with the speed of gastric mucosa regeneration in artificial gastric ulcers / J Gastroenterol Hepatol 29:736~741
Kangwan N / 2014 / Quality of healing of gastric ulcers : natural products beyond acid suppression / World J Gastrointest Pathophysiol 5:40~47
Harada S / 2015 / The availability of prostaglandin derivatives in a treatment and prevention for gastrointestinal mucosal injury / Nihon Rinsho 73:1153~1158
Sugiyama T / 2015 / Mucosal protective drugs / Nihon Rinsho 73:1147~1152
Samsonov AA / 2014 / Pharmacoeconomic evaluation of treatment in patients with Helicobacter pylori-associated diseases / Ter Arkh 86:56~61
Kangwan N / 2014 / Quality of healing of gastric ulcers : natural products beyond acid suppression / World J Gastrointest Pathophysiol 5:40~47
Harada S / 2015 / The availability of prostaglandin derivatives in a treatment and prevention for gastrointestinal mucosal injury / Nihon Rinsho 73:1153~1158
Sugiyama T / 2015 / Mucosal protective drugs / Nihon Rinsho 73:1147~1152
Samsonov AA / 2014 / Pharmacoeconomic evaluation of treatment in patients with Helicobacter pylori-associated diseases / Ter Arkh 86:56~61
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