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논문 기본 정보

자료유형
학술저널
저자정보
Ki-Taek Oh (Yonsei University Wonju College of Medicine) Mee Kyung Namgoong (Yonsei University Wonju College of Medicine) Yeong-Myong Yoo (Yonsei University Wonju College of Medicine) Byoung-Kook Lee (Chungnam National University Sejong Hospital)
저널정보
대한주산의학회 Perinatology Perinatology Vol.32 No.1
발행연도
2021.1
수록면
48 - 53 (6page)

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Renin-angiotensin system (RAS) has a significant role in the regulation of blood pressure. The use of RAS blocker (angiotensin converting enzyme inhibitor or angiotensin II receptor blocker [ARB]) for hypertension is common, but this medication during pregnancy may lead to dysgenesis of renal tubule, hypoperfusion and hypoplastic growth of skull and pulmonary vascular hypoplasia in fetus. We report a female baby born to a mother who took ARB up to gestational age 35 weeks, and then did not take ARB for 10 days until delivery on IUP 36+3 weeks. The baby suffered from hypotension and anuria for few days but suffered severe respiratory difficulty and pulmonary hypertension requiring mechanical ventilation with inhalation of nitric oxide. The baby had also limb contracture, defects of skull ossification, and thrombocytosis. After weaning of mechanical ventilation, the baby had a polyuria and was diagnosed with transient partial nephrogenic diabetes insipidus. The baby showed polycythemia with normal kidney function at 20 months of age. The baby showed normal growth and development based on the results of the Korean Development Screening Test with 20 months of corrected ages.

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