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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제1호
- 발행연도
- 2018.1
- 수록면
- 35 - 42 (8page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.1.35
이용수
초록· 키워드
오류제보하기
Ascorbic acid is one of the most well-known nutritional supplement and antioxidant found in fruits and vegetables. Calcium ascorbate has been developed to mitigate the gastric irritation caused by the acidity of ascorbic acid. The aim of this study was to compare calcium ascorbate and ascorbic acid, focusing on their antioxidant activity and effects on gastric juice pH, total acid output, and pepsin secretion in an in vivo rat model, as well as pharmacokinetic parameters. Calcium ascorbate and ascorbic acid had similar antioxidant activity. However, the gastric fluid pH was increased by calcium ascorbate, whereas total acid output was increased by ascorbic acid. In the rat pylorus ligation-induced ulcer model, calcium ascorbate increased the gastric fluid pH without changing the total acid output. Administration of calcium ascorbate to rats given a single oral dose of 100 mg/kg as ascorbic acid resulted in higher plasma concentrations than that from ascorbic acid alone. The area under the curve (AUC) values of calcium ascorbate were 1.5-fold higher than those of ascorbic acid, and the Cmax value of calcium ascorbate (91.0 ng/ml) was higher than that of ascorbic acid (74.8 ng/ml). However, their Tmax values were similar. Thus, although calcium ascorbate showed equivalent antioxidant activity to ascorbic acid, it could attenuate the gastric high acidity caused by ascorbic acid, making it suitable for consideration of use to improve the side effects of ascorbic acid. Furthermore, calcium ascorbate could be an appropriate antioxidant substrate, with increased oral bioavailability, for patients with gastrointestinal disorders.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Valdes F / 2006 / Vitamin C / Actas Dermosifiliogr 97:557~568
Naidu KA / 2003 / Vitamin C in human health and disease is still a mystery? An overview / Nutr J 2:7
Padayatty SJ / 2003 / Vitamin C as an antioxidant: evaluation of its role in disease prevention / J Am Coll Nutr 22:18~35
Carr A / 1999 / Does vitamin C act as a pro-oxidant under physiological conditions? / FASEB J 13:1007~1024
Martin A / 1997 / Both intracellular and extracellular vitamin C inhibit atherogenic modification of LDL by human vascular endothelial cells / Arterioscler Thromb Vasc Biol 17:1583~1590
Naidu KA / 2003 / Vitamin C in human health and disease is still a mystery? An overview / Nutr J 2:7
Padayatty SJ / 2003 / Vitamin C as an antioxidant: evaluation of its role in disease prevention / J Am Coll Nutr 22:18~35
Carr A / 1999 / Does vitamin C act as a pro-oxidant under physiological conditions? / FASEB J 13:1007~1024
Martin A / 1997 / Both intracellular and extracellular vitamin C inhibit atherogenic modification of LDL by human vascular endothelial cells / Arterioscler Thromb Vasc Biol 17:1583~1590
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