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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 353 - 360 (8page)
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초록· 키워드
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Purpose: To describe the clinical manifestations of herpes simplex keratitis (HSK) in a tertiary referral center in South Korea and to determine whether ascorbic acid treatment prevents recurrence of herpetic epithelial keratitis. Methods: This retrospective cohort study included all consecutive patients with herpetic keratitis referred to our center from January 2010 to January 2015. Clinical features, ocular complications, and recurrences were recorded. Results: In total, 149 eyes of the 133 patients (72 male and 61 female) were followed for an average of 24.6 ± 13.2 months. Sixteen (12.0%) patients had bilateral HSK. The most frequent HSK subtype was epithelial keratitis (49.7%), which was followed by stromal keratitis (23.5%). Epithelial keratitis was the most likely subtype to recur. Complications occurred in 122 (81.9%) eyes. The most common complication was corneal opacity. Recurrences were observed in 48 (32.2%) eyes. The recurrence rates were lower in the prophylactic oral antiviral agent group (16 / 48 eyes, 33.3% vs. 49 / 101 eyes, 48.5%) and the ascorbic acid treatment group (13 / 48 eyes, 27.1% vs. 81 / 101 eyes, 70.3%) compared with the groups without medications. Univariate logistic regression analysis revealed that both factors significantly reduced the risk of recurrence (acyclovir: odds ratio, 0.25; 95% confidence intervals, 0.12 to 0.51; ascorbic acid: odds ratio, 0.51; 95% confidence intervals, 0.20 to 0.91). Conclusions: This retrospective study described the clinical findings of HSK in a tertiary referral center in South Korea. Prophylactic oral antiviral agent treatment and oral ascorbic acid administration may lower the risk of recurrence.
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참고문헌 (21)
참고문헌 신청
Liesegang TJ / 2001 / Herpes simplex virus epidemiology and ocular importance / Cornea 20:1~13
Liesegang TJ / 1989 / Epidemiology of ocular herpes simplex: incidence in Rochester, Minn, 1950 through 1982 / Arch Ophthalmol 107:1155~1159
Kaye S / 2006 / Herpes simplex keratitis / Prog Retin Eye Res 25:355~380
1996 / A controlled trial of oral acyclovir for iridocyclitis caused by herpes simplex virus. The Herpetic Eye Disease Study Group / Arch Ophthalmol 114:1065~1072
Schwartz GS / 2000 / Oral acyclovir for the management of herpes simplex virus keratitis in children / Ophthalmology 107:278~282
Liesegang TJ / 1989 / Epidemiology of ocular herpes simplex: incidence in Rochester, Minn, 1950 through 1982 / Arch Ophthalmol 107:1155~1159
Kaye S / 2006 / Herpes simplex keratitis / Prog Retin Eye Res 25:355~380
1996 / A controlled trial of oral acyclovir for iridocyclitis caused by herpes simplex virus. The Herpetic Eye Disease Study Group / Arch Ophthalmol 114:1065~1072
Schwartz GS / 2000 / Oral acyclovir for the management of herpes simplex virus keratitis in children / Ophthalmology 107:278~282
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