지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제2호
- 발행연도
- 2017.3
- 수록면
- 251 - 257 (7page)
이용수
초록· 키워드
오류제보하기
Inhibition of K+ outward currents by linopirdine in the outer hair cells (OHCs) of circling mice (homozygous (cir /cir ) mice), an animal model for human deafness (DFNB6 type), was investigated using a whole cell patch clamp technique.
Littermate heterozygous (+/cir ) and ICR mice of the same age (postnatal day (P) 0 ?P6) were used as controls. Voltage steps from ?100 mV to 40 mV elicited small inward currents (?100 mV~?70 mV) and slow rising K+ outward currents (?60 mV ~40 mV) which activated near ?50 mV in all OHCs tested. Linopirdine, a known blocker of K+ currents activated at negative potentials (I K,n), did cause inhibition at varying degree (severe, moderate, mild) in K+ outward currents of heterozygous (+/cir ) or homozygous (cir /cir ) mice OHCs in the concentration range between 1 and 100 mM, while it was apparent only in one ICR mice OHC out of nine OHCs at 100 mM. Although the half inhibition concentrations in heterozygous (+/cir ) or homozygous (cir /cir ) mice OHCs were close to those reported in I K,n, biophysical and pharmacological properties of K+ outward currents, such as the activation close to ?50 mV, small inward currents evoked by hyperpolarizing steps and TEA sensitivity, were not in line with I K,n reported in other tissues. Our results show that the delayed rectifier type K+ outward currents, which are not similar to I K,n with respect to biophysical and pharmacological properties, are inhibited by linopirdine in the developing (P0~P6) homozygous (cir /cir ) or heterozygous (+/cir ) mice OHCs.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Marcotti W / 2003 / Developmental changes in the expression of potassium currents of embryonic, neonatal and mature mouse inner hair cells / J Physiol 548:383~400
Marcotti W / 1999 / Transient expression of an inwardly rectifying potassium conductance in developing inner and outer hair cells along the mouse cochlea / Pflugers Arch 439:113~122
Dulon D / 1998 / Expression of small-conductance calcium-activated potassium channels(SK)in outer hair cells of the rat cochlea / Eur J Neurosci 10:907~915
Roux I / 2011 / Onset of cholinergic efferent synaptic function in sensory hair cells of the rat cochlea / J Neurosci 31:15092~15101
Marcotti W / 1999 / Developmental expression of the potassium current I K, n contributes to maturation of mouse outer hair cells / J Physiol 520:653~660
Marcotti W / 1999 / Transient expression of an inwardly rectifying potassium conductance in developing inner and outer hair cells along the mouse cochlea / Pflugers Arch 439:113~122
Dulon D / 1998 / Expression of small-conductance calcium-activated potassium channels(SK)in outer hair cells of the rat cochlea / Eur J Neurosci 10:907~915
Roux I / 2011 / Onset of cholinergic efferent synaptic function in sensory hair cells of the rat cochlea / J Neurosci 31:15092~15101
Marcotti W / 1999 / Developmental expression of the potassium current I K, n contributes to maturation of mouse outer hair cells / J Physiol 520:653~660
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Characteristics of K+ Outward Currents in the Cochlear Outer Hair Cells of Circling Mice within the First Postnatal Week
The Korean Journal of Physiology & Pharmacology
2015 .07
-
Over-expression of myosin7A in cochlear hair cells of circling mice
한국실험동물학회 학술발표대회 논문집
2017 .08
-
Early-onset hearing loss by apoptosis of cochlear spiral ganglion neurons in heterozygous circling (C57BL/6J-+/cir) mouse
한국실험동물학회 학술발표대회 논문집
2020 .02
-
Methods for Assessing Efficacy of Hair Re-growth in Telogen Mice
한국실험동물학회 학술발표대회 논문집
2016 .08
-
From breeding mouse to editing mouse genome
한국실험동물학회 학술발표대회 논문집
2017 .08
-
黃芪 추출물의 외용 도포가 자발성 원형탈모 생쥐에 미치는 영향
대한한의학회지
2018 .03
-
The formation of V-shaped hair bundle architecture in cochlear hair cells
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Expression of p63 and its association with cell proliferation at different stages of murine hair follicle cycle
Journal of Biomedical and Translational Research
2018 .03
-
Hair Growth Promoting Potential of Phospholipids Purified from Porcine Lung Tissues
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
-
Mice vs. Men
한국실험동물학회 학술발표대회 논문집
2016 .08
-
The mouse one portal(MOP), all Information for all mice
한국실험동물학회 학술발표대회 논문집
2020 .02
-
한방추출 천연혼합물의 탈모 유발 쥐에 대한 발모 효과
동의생리병리학회지
2019 .12
-
Hair Growth-Promoting Effects of Lavender Oil in C57BL/6 Mice
Toxicological Research
2016 .04
-
Generation of four mouse models for human cancer by engineered nucleases
한국실험동물학회 학술발표대회 논문집
2017 .02
-
A Comprehensive Mouse Phenotyping Platform in the Japan Mouse Clinic
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Hearing Improvement in A/J Mice via the Mouse Nerve Growth Factor
Clinical and Experimental Otorhinolaryngology
2017 .01
-
Hair Cell Regeneration: From Animals to Humans
Clinical and Experimental Otorhinolaryngology
2024 .02
-
Hair follicle stem cells and mitochondria
대한미용의학회지
2023 .06
-
The Presence of Neural Stem Cells and Changes in Stem Cell-Like Activity With Age in Mouse Spiral Ganglion Cells In Vivo and In Vitro
Clinical and Experimental Otorhinolaryngology
2018 .01
-
The distribution of Calbindin D-28k, parvalbumin, and calretinin immunoreactivity in the cochlear nuclear complex
대한체질인류학회 학술대회 연제 초록
2021 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0