지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제1호
- 발행연도
- 2017.1
- 수록면
- 133 - 140 (8page)
이용수
초록· 키워드
오류제보하기
Conflicting evidence has been obtained regarding whether transient receptor potential cation channels (TRPC) are store-operated channels (SOCs) or receptor-operated channels (ROCs). Moreover, the Ca/Na permeability ratio differs depending on whether the current-voltage (I-V) curve has a doubly rectifying shape or inward rectifying shape. To investigate the calcium permeability of TRPC4 channels, we attached GCaMP6s to TRPC4 and simultaneously measured the current and calcium signals. A TRPC4 specific activator, (?)-englerin A, induced both current and calcium fluorescence with the similar time course. Muscarinic receptor stimulator, carbachol, also induced both current and calcium fluorescence with the similar time course. By forming heteromers with TRPC4, TRPC1 significantly reduced the inward current with outward rectifying I-V curve, which also caused the decrease of calcium fluorescence intensity. These results suggest that GCaMP6s attached to TRPC4 can detect slight calcium changes near TRPC4 channels. Consequently, TRPC4- GCaMP6s can be a useful tool for testing the calcium permeability of TRPC4 channels.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Montell C / 1989 / Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction / Neuron 2:1313~1323
Nilius B / 2005 / TRP channels: a TR(I)P through a world of multifunctional cation channels / Pflugers Arch 451:1~10
Putney JW / 2005 / Physiological mechanisms of TRPC activation / Pflugers Arch 451:29~34
Brough GH / 2001 / Contribution of endogenously expressed Trp1 to a Ca2+-selective, store-operated Ca2+ entry pathway / FASEB J 15:1727~1738
Freichel M / 2001 / Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/-mice / Nat Cell Biol 3:121~127
Nilius B / 2005 / TRP channels: a TR(I)P through a world of multifunctional cation channels / Pflugers Arch 451:1~10
Putney JW / 2005 / Physiological mechanisms of TRPC activation / Pflugers Arch 451:29~34
Brough GH / 2001 / Contribution of endogenously expressed Trp1 to a Ca2+-selective, store-operated Ca2+ entry pathway / FASEB J 15:1727~1738
Freichel M / 2001 / Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/-mice / Nat Cell Biol 3:121~127
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