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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 45 - 52 (8page)
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초록· 키워드
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Calcium has versatile roles in diverse physiological functions. Among these functions, intracellular Ca<SUP>2+</SUP> plays a key role during the secretion of salivary glands. In this review, we introduce the diverse cellular components involved in the saliva secretion and related dynamic intracellular Ca<SUP>2+</SUP> signals. Calcium acts as a critical second messenger for channel activation, protein translocation, and volume regulation, which are essential events for achieving the salivary secretion. In the secretory process, Ca<SUP>2+</SUP> activates K<SUP>+</SUP> and Cl<SUP>–</SUP> channels to transport water and electrolyte constituting whole saliva. We also focus on the Ca<SUP>2+</SUP> signals from intracellular stores with discussion about detailed molecular mechanism underlying the generation of characteristic Ca<SUP>2+</SUP> patterns. In particular, inositol triphosphate signal is a main trigger for inducing Ca<SUP>2+</SUP> signals required for the salivary gland functions. The biphasic response of inositol triphosphate receptor and Ca<SUP>2+</SUP> pumps generate a self-limiting pattern of Ca<SUP>2+</SUP> efflux, resulting in Ca<SUP>2+</SUP> oscillations. The regenerative Ca<SUP>2+</SUP> oscillations have been detected in salivary gland cells, but the exact mechanism and function of the signals need to be elucidated. In future, we expect that further investigations will be performed toward better understanding of the spatiotemporal role of Ca<SUP>2+</SUP>signals in regulating salivary secretion.
목차
Introduction
The Role of Calcium in Salivary Glands
The Intracellular Calcium Stores Involved in the Secretory Process
The Pattern of Calcium Release Including Calcium Oscillation
Experimental Detection of Ca2+ Oscillation in Salivary Gland Cells and Future Perspectives
References
참고문헌 (48)
참고문헌 신청
[학술지(정기간행물)] - Närhi TO / 1999 / Xerostomia and hyposalivation: causes, consequences and treatment in the elderly / Drugs Aging 15 : 103 ~ 116
[학술지(정기간행물)] - Petersen OH / 1992 / Stimulus-secretion coupling : cytoplasmic calcium signals and the control of ion channels in exocrine acinar cells / J Physiol 448 : 1 ~ 51
[학술지(정기간행물)] - Park KP / 1994 / Ca(2+)-activated K+ channels are involved in regulatory volume decrease in acinar cells isolated from the rat lacrimal gland / J Membr Biol 141 : 193 ~ 201
[학술지(정기간행물)] - Catalán MA / 2014 / Ca2+-dependent K+ channels in exocrine salivary glands / Cell Calcium 55 : 362 ~ 368
[학술지(정기간행물)] - Sung-ManCho / 2002 / Characterization of Intermediate Conductance K+ Channels in Submandibular Gland Acinar Cells / The Korean Journal of Physiology & Pharmacology 6 (6) : 305 ~ 309
[학술지(정기간행물)] - Petersen OH / 1992 / Stimulus-secretion coupling : cytoplasmic calcium signals and the control of ion channels in exocrine acinar cells / J Physiol 448 : 1 ~ 51
[학술지(정기간행물)] - Park KP / 1994 / Ca(2+)-activated K+ channels are involved in regulatory volume decrease in acinar cells isolated from the rat lacrimal gland / J Membr Biol 141 : 193 ~ 201
[학술지(정기간행물)] - Catalán MA / 2014 / Ca2+-dependent K+ channels in exocrine salivary glands / Cell Calcium 55 : 362 ~ 368
[학술지(정기간행물)] - Sung-ManCho / 2002 / Characterization of Intermediate Conductance K+ Channels in Submandibular Gland Acinar Cells / The Korean Journal of Physiology & Pharmacology 6 (6) : 305 ~ 309
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UCI(KEPA) : I410-ECN-0101-2018-515-001679184