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Hypertrophic Cardiomyopathy in Infants from the Perspective of Cardiomyocyte Maturation
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논문 기본 정보

Type
Academic journal
Author
HEE YOUNG SEOK (서울대학교병원) Jin-Hee Oh (St. Vincent's Hospital)
Journal
The Korean Society of Cardiology Korean Circulation Journal Korean Circulation Journal Vol.51 No.9 KCI Accredited Journals
Published
2021.9
Pages
733 - 751 (19page)
DOI
https://doi.org/10.4070/kcj.2021.0153

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Hypertrophic Cardiomyopathy in Infants from the Perspective of Cardiomyocyte Maturation
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Hypertrophic cardiomyopathy (HCM) is characterized by ventricular wall hypertrophy with diastolic dysfunction. Pediatric HCM is distinguished from the adult in many aspects. Most children with HCM do not present clinically until the adolescent period, even when they are born with genetic mutations. Some infants with early-onset HCM present with massive progressive myocardial hypertrophy in the first few months of life, which is often fatal. The mortality of pediatric HCM peaks during the infantile and adolescent periods. These periods roughly correlate with children's growth spurt. Non-sarcomeric causes of HCM are more frequent in pediatric HCM, while sarcomeric causes are more common in adults. From the perspective of cardiac development, the fetal heart has immature cardiomyocytes, which are characterized by proliferation and exit their cell cycles with a decreased regenerative property after birth. In the perinatal period, there is a dynamic change in maturation of cardiomyocytes from immature to mature cells. Infants who are treated with steroids or born to mothers with diabetes or hyperthyroidism often show phenotypes of HCM, which gradually resolve. With remarkable advancement of molecular biology, understanding on maturation of cardiomyocytes has increased. Neonates undergo abrupt environmental changes during the transitional circulation, which is affected by oxygen, metabolic and hormonal fluctuations. Derangement in physiological transition to the normal postnatal environment may influence maturation of proliferative immature cardiomyocytes during early infancy. This article reviews updates of infantile HCM and recent molecular studies related to maturation of cardiomyocytes from the clinical point of view of identifying distinct characteristics of infantile HCM.
#Cardiomyopathy #Hypertrophic #Cardiomyocytes #Maturation #Infant

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References (10)

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최병민 / 2013 / A Case of Congenital Hypertrophic Cardiomyopathy / Korean Circulation Journal 43(1):54~56 google schola Seok Heeyoung / 2021 / Application of CRISPR-Cas9 gene editing for congenital heart disease / Clinical and Experimental Pediatrics 64(6):269~279 Crossref Koda M / 2006 / Nuclear hypertrophy reflects increased biosynthetic activities in myocytes of human hypertrophic hearts / Circ J 70:710~718 google schola Haubner BJ / 2012 / Complete cardiac regeneration in a mouse model of myocardial infarction / Aging(Albany NY) 4:966~977 google schola D'Uva G / 2015 / ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation / Nat Cell Biol 17:627~638 google schola

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