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논문 기본 정보

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저자정보
Bae Nan Young (Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.) Rhee Tae-Min (Department of Internal Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea.) Park Chan Soon (Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.) Choi You-Jung (Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.) Lee Hyun-Jung (Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.) Choi Hong-Mi (Cardiovascular Center and Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.) Park Jun-Bean (Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.) Yoon Yeonyee E. (Cardiovascular Center and Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.) Kim Yong-Jin (Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.) Cho Goo-Yeong (Cardiovascular Center and Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.) Hwang In-Chang (Cardiovascular Center and Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.) Kim Hyung-Kwan (Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.39 No.8
발행연도
2024.3
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1 - 13 (13page)
DOI
10.3346/jkms.2024.39.e80

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Background: The association between renal dysfunction and cardiovascular outcomes has yet to be determined in patients with hypertrophic cardiomyopathy (HCM). We aimed to investigate whether mildly reduced renal function is associated with the prognosis in patients with HCM. Methods: Patients with HCM were enrolled at two tertiary HCM centers. Patients who were on dialysis, or had a previous history of heart failure (HF) or stroke were excluded. Patients were categorized into 3 groups by estimated glomerular filtration rate (eGFR): stage I (eGFR ≥ 90 mL/min/1.73 m2 , n = 538), stage II (eGFR 60–89 mL/min/1.73 m2 , n = 953), and stage III–V (eGFR < 60 mL/min/1.73 m2 , n = 265). Major adverse cardiovascular events (MACEs) were defined as a composite of cardiovascular death, hospitalization for HF (HHF), or stroke during median 4.0-year follow-up. Multivariable Cox regression model was used to adjust for covariates. Results: Among 1,756 HCM patients (mean 61.0 ± 13.4 years; 68.1% men), patients with stage III–V renal function had a significantly higher risk of MACEs (adjusted hazard ratio [aHR], 2.71; 95% confidence interval [CI], 1.39–5.27; P = 0.003), which was largely driven by increased incidence of cardiovascular death and HHF compared to those with stage I renal function. Even in patients with stage II renal function, the risk of MACE (vs. stage I: aHR, 2.21’ 95% CI, 1.23–3.96; P = 0.008) and HHF (vs. stage I: aHR, 2.62; 95% CI, 1.23–5.58; P = 0.012) was significantly increased. Conclusion: This real-world observation showed that even mildly reduced renal function (i.e., eGFR 60–89 mL/min/1.73 m2 ) in patients with HCM was associated with an increased risk of MACEs, especially for HHF.
#Hypertrophic Cardiomyopathy #Renal Function #Glomerular Filtration Rate #Prognosis #Heart Failure

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